ホーム > 業績
〒920-8640
石川県金沢市宝町13-1
13-1 Takaramachi, Kanazawa City, Ishikawa Prefecture 920-8640
医局長 佐藤保則
Tel 076-265-2199
mail sato-ya@med.kanazawa-u.ac.jp
事務担当 髙橋健太
Tel 076-265-2197
mail ktakahashi@staff.kanazawa-u.ac.jp
英文論文
・Pathologidal findings of nonalcoholic steatohepatitis and nonalcoholic fatty liver disease.
Sakamoto M, Tsujikawa H, Effendi K, Ojima H, Harada K, Zen Y, Kondo F, Nakano M,
Kage M, Sumida Y, Hashimoto E, Yamada G, Okanoue T, Koike K.
Pathol Int. 2017 Jan;67(1):1-7 doi: 10.1111/pin.12485. No abstract available.
・Genome-wide association studies identify PRKCB as a novel genetic susceptibility locus for
primary biliary cholangitis in the Japanese population. Kawashima M, Hitomi Y, Aiba Y,
Nishida N,Kojima K, kawai Y, ... Harada K, et al. Hum Mol Genet. 2017 Jan 5.
pii:ddw406. doi: 10.1093/hmg/ddw406.
・Mutational landscape combined hepatocellular carcinoma and cholangiocarcinoma, and its
clinicopathological significance. Sasaki M, Sato Y, Nakanuma Y. Histopathology 2017
70,423-434 Doi:10.1111/his.13084
・Stress-induced cellular responses and cell death mechanisms during inflammatory
cholangiopathies. Sasaki M, Nakanuma Y. Clinics and Research in Hepatology and
Gastroenterology 2017(41):129-138
・Bile Acids and Deregulated cholangiocyte Autophagy in Primary Biliary Cholangitis.
Sasaki M, Nakanuma Y. Dig Dis 2017;35:210-216 DOI: 10.1159/000450913
・Expression and localization of sterile alpha motif domain containing 5 is associated with
cell type and malignancy of biliary tree. Yagai T, Matsui S, Harada K, Inagaki F, Saijou E,
Miura Y, Nakanuma Y, Miyajima A, Tanaka M. PLos One. 2017 7;12(4):e0175355.
doi: 10.1371/journal.pone.0175355. eCollection 2017.
・Genetic analyses of isolated high-grade pancreatic intraepithelial neoplasia(HG-PanIN)
rebeal paucity of ations in TP53 and SMAD4. Hosoda W, Chianchiano P, Griffin JF,
Pittman ME, Brosens LA, Noe M, Yu J, Shindo K, Suenaga M, Rezaee N, Yonescu R,
Ning Y, Alberos-Saavedra J, Yoshizawa N, Harada K, Yoshizawa A, Hanada K, Yonehara S,
Shimizu M, Uehara T, Samra JS, Gill AJ, Wolfgang CL, Goggins MG, Hruban RH, Wood LD.
J Pathol. 2017 Feb 11. doi: 10.1002/path.4884.
・The PD-1/PD-L1 axis may be aberratly activated in occupational cholangiocarcinoma.
Yasunori Sato, Masahiko Kinoshita, Shigekazu Takemura, Shogo Tanaka, Genya Hamano,
Shoji Nakamori, Masahiro Fujikawa, Yasuhiko Sugawara, Takatsugu Yamamoto,
Akira Arimoto, Minako Yamamura, Motoko Sasaki, Kenichi Harada, Yasuni Nakanuma,
and Shoji Kubo. Pathol Int. 2017 67:163-170 doi: 10.1111/pin.12511
・Insulin-like growth factor Ⅱ mRNA-binding protein3(IMP3) is a marker that predicts
presence of invasion in papillary biliary tumors. Motoko Sasaki, Yasunori Sato.
Human Pathology 2017 62:152-159
・Rathke Cleft Cyst with Entirely Ossified Cyst Wall and Partially Solid Cyst Contest:
A Case Report and Literature Review. Yasuhiko Hayashi, Masahiro Oishi, Issei Fukui,
Yasuo Sasagawa, Kenichi Harada, Mitsutoshi Nakada. World Neurosurgery 2017
98:Pages 882.e15-882.e20
・Acute presentation of autoimmune hepatitis: a multicentre study with detailed histological
evalution in a large cohort of patients. Nguyen canh H, Harada K, Ouchi h, Sato y,
Tsuneyama K, kage M, Nakano M, Yoshizawa K, Takahashi A, Abe M, Kang JH, Koike k,
Inui a, Fujisawa T, Takaki A, Arinaga-Hino T, Torimura t, Suzuki Y, Fujiwara K, Zeniya M,
Ohira H, Tanaka A, Takikawa H; Intractable Liver and Biliary Diseases Study Group of
Japan. J Clin pathol. 2017 Apr 20. pii:jclinpath-2016-204271
doi: 10.1136/jclinpath-2016-204271.
・The simultaneous inhibition of the mTOR and MAPK pathways with Gnetin-C induces
apoptosis in acute myeloid leukemia. J.luis espinoza, Mahmoud I.Elbadry, Masafumi
Taniwaki, Kenichi Harada, Ly Quoc Trung, Noriharu Nakagawa, Akiyoshi Takami, Ken
Ishiyama, Takuji Yamauchi, Katsuto Takenaka, Shinji Nakao. Cancer Letters 2017
400:127-136
・Safety, Tolerability, and preliminary Efficacy of the Anti-Fibrotic Small Molecule PRI-724,
a CBP/β-catenin inhibitor, in Patients with Hepatitis C Virus-related Cirrhosis:
A Single-Center, Open-Label, Dose Escalation Phase 1 Trial. Kimura K, Ikoma A,
Shibakawa M,Shimoda S, Harada K, Saio M, Imamura J, Osawa Y, Kimura M,
Nishikawa K, Okusaka T, Morita S, Inoue K, Kanto T, Todaka K, nakanishi Y, Kohara M,
Mizokami M. E Bio Medicine 2017 Aug 19. doi: 10.1016/j.ebion.2017.08.016
・Challenges and difficulties in pathological diagnosis of autoimmune hepatitis.
Harada K, Hiep NC, Ohira H. Hepatol Res. 2017 Sep;47(10): 963-971
doi: 10.1111/hepr.12931
・Diagnostic sensitivity of cutoff values of IgG4-posotove plasma cell number and
IgG4-positive/CD138-positive cell ratio in typical multiple lesions of patients with
IgG4-related disease. Mizushima i, Yamada K, Harada K, Matsui S, Saeki T, Kondo S,
Takahira M, Waseda Y, Hamaguchi Y, Fujii H, Yamagishi M, Kawano M.
Mod Rheumatol. 2017 22:1-7 doi:10.1080/14397595.2017.1332540.
・Gadoxetic acid-enhanced magnetic resonance imaging reflects co-activation of β-catenin
and hepatocyte nuclear factor 4α in hepatocellular carcinoma. Kitao A, Matsui O,
Yoneda N, Kozaka K, Kobayashi S, Koda W, Minami T, Inoue D, Yoshida K, Yamashita T,
Yamashita T, Kaneko S, Takamura H, ohta t, Ikeda H, Sato Y, Nakanuma Y, Harada K,
Kita R, Gabata T. Hepatol Res. 2017 doi: 10.1111/hepr.12911
・A case of ruptured hepatocellular carcinoma(HCC) in resolving non-alcoholic
steatohepatitis associated with type 2 diabetes: Is early detection of diabetes-related
HCC feasible? Ikura Y, Tiniakos DG, Tanaka T, Harada K.
J Diabetes. 2017;9(3):311-313 doi: 10.1111/1753-0407.12493 Epub 2016 Nov 24
・Clinical features of cystatin A expression in patients with pancreatic ductal
adenocarcinoma. Komura t, Takabatake h, Harada K, Yamato M, miyazawa M,
Yoshida K, Honda M, Wada T, Kitagawa H, Ohta T, Kaneko S, Sakai Y.
Cancer Sci. 2017 doi:10.1111/cas.13396
・Sclerosing and abstructive cholangiopathy in biliary atresia: mechanisms and association
with biliary innate immunity. Kenichi Harada Pediatr Surg Int 2017
DOI 10.1007/s00383-017-4154-8
・Clinicopathological Study of Autoimmune Hepatitis Cases That Were Difficult to
Differentiate from Drug-Induced Liver Injury. Tsutsui A, Harada K, Tsuneyama K,
Senoh T, nagano T, Takeguchi K, Ando M, Nakamura S, Mizobuchi K, Kudo M.
Dig dis. 2017;35(6):506-514. doi:10.1159/000480139. Epub 2017 Oct 17.
・BRAF V600E, TERT promoter mutations and CDKN2A/B homozygous deletions are
frequent in epithelioid glioblastomas: A histological and molecular analysis focusing on
intratumoral heterogeneity. Nakajima N, Nobusawa S, Nakata S, Nakada M, yamazaki T,
Matsumura N, Harada K, matsuda H, Funata N, Nagai S, Nakamura H, Sasaki A, Akimoto J,
Hirato J, Yokoo H. Brain Pathol. 2017 Nob 4. doi:10.1111/bpa.12572.
・Role for Neutrophil Extracellular Traps(NETs) and Platelet Agguregation in Early
Sepsos-induced Hepatic Dysfunction. Sakurai K, Miyashita T, Okazaki M, Yamaguchi T,
Ohbatake Y, Nakanuma S, Okamoto K, Sakai S, Kinoshita J, Makino I, Nakamura K,
Hayashi H, Oyama K, Tajima H, Takamura H, Ninomiya I, Fushida S, Harada K,
Harmon JW, Ohta T. In Bivo. 2017 Nov-Dec; 31(6): 1051-1058
・Usefulness of laparoscopy and intraductal ultrasonography in a patient with isolated
immunogloblin G4-related sclerosing cholangitis. Ohno Y, Kumagi T, Imamura Y,
Kuroda T, Koizumi M, Watanabe T, Yoshida O, Tokumoto Y, Takeshita E, Abe M,
Harada K, Hiasa Y.
Clin J Gastroenterol. 2017 Nov 1 doi: 10.1007/s12328-017-0787-3
・ Unclassified hepatocellular adenoma in a middle-aged woman with glucose intolerance.
Ozaki K, Harada K, Yamamoto T, Aoyagi H, Kaizaki Y, Yoshikawa J.
Clin J Gastroeenterol. 2017 doi: 10.1007/s12328-017-0788-2.
英文著書・分担執筆等
・Pathology of the Bile Duct Editor Yasuni Nakanuma
Chapter10 Immunopathology of Biliary Atresia P121-137
Kenichi Harada Springer 2017 総ページ数:212ページ
・Pathology of the Bile Duct Editor Yasuni Nakanuma
Chapter4 Cellular Senescence and Biliary Disorders P39-54
Motoko Sasaki Springer 2017 総ページ数:212ページ
・Pathology of the Bile Duct Editor Yasuni Nakanuma
Chapter14 Cystic and micropapillary Neoplasm of peribiliary Glands:
Its perspective to Cholangiocarcinogenesis P177-188
Yasunori Sato Springer 2017 総ページ数:212ページ
・Biliary Diseases with Pancreatic Counterparts Editor Yasuni Nakanuma
Chapter3 IgG4-Related Sclerosing Cholangitis and Type1 Autoimmune Pancreatitis
Kenichi Harada NOVA 2017 総ページ:271ページ P47-61
・Biliary Diseases with Pancreatic Counterparts Editor Yasuni Nakanuma
Chapter10 Mucinous cystic Neoplasm of the Liver and Pancreas P199-215
Motoko Sasaki NOVA 2017 総ページ:271ページ
・Biliary Diseases with Pancreatic Counterparts Editor Yasuni Nakanuma
Chapter6 Biliary Intraepithelial Neoplasia and Pancreatic Intraepithelial Neoplasia
Yasunori Sato NOVA 2017 総ページ:271ページ P111-136
特別講義・講演
・原田 憲一
教育講演「自己免疫性肝疾患のトピック」
第125回日本消化器病学会北陸支部例会 第38回教育講演会
(平成29年11月5日、石川県地場産業振興センター 金沢市)招待講演
・原田 憲一
教育講演「自己免疫性肝炎の病理」
第45回「Liver Disease Working Group」
(平成29年11月9日、帝京大学医学部 東京都)招待講演
・原田 憲一
基調講演「肝線維化の病態と治療戦略」
第21回日本肝臓学会大会 JDDW2017
(平成29年10月12日、福岡国際会議場 福岡市)招待講演
・原田 憲一、下田 慎治
「原発性胆汁性胆管炎における胆管細胞の老化と病態形成」
第17回日本抗加齢医学会総会
(平成29年6月2日、東京国際フォーラム)招待講演
・Harada K.
「Mechanisms of the sclerosing and obstructive cholangiopathy in biliary atresia:
Association with biliary innate immunity.」
ISSBA シンポジウム2 Etiology and Pathophysiology
第7回胆道閉鎖症仙台国際シンポジウム
(平成29年5月12日、仙台国際センター)招待講演
・原田 憲一
「初学者のための病理」
School of AutoImmune Liver Disease(SAIL)
「難治性の肝・胆道疾患に関する調査研究班」主催 招待講演
(平成29年1月7日、セミナーハウス クロス・ウェーブ幕張)