金沢大学医薬保健研究域医学系 人体病理学教室 （第2病理学教室）

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業績

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〒920-8640
石川県金沢市宝町13-1

13-1 Takaramachi, Kanazawa City, Ishikawa Prefecture 920-8640

医局長　佐藤保則
Tel 076-265-2199
mail sato-ya@med.kanazawa-u.ac.jp

事務担当　髙橋健太
Tel 076-265-2197
mail ktakahashi@staff.kanazawa-u.ac.jp

金沢大学附属病院

業績Results

2012年

英文論文

  • Tsuneyama K, Moritoki Y, Kikuchi K, Nakanuma Y. Pathological features of new animal models for primary biliary cirrhosis. International Journal of Hepatology vol. 2012 (2012), Article ID 403954, 7 pages, 2012. doi: 10.1155/2012/403954.
  • Sato Y, Ren Xiang Shan, Nakanuma Y. Caroli’s disease: Current knowledge of its biliar y pathogenesis obtained from an orthologous rat model. International Journal of Hepatology vol. 2012 (2012), Article ID 107945, 10 pages, 2012. doi: 10.1155/2012/107945.
  • Sasaki M, Nakanuma Y. Novel approach to bile duct damage in primary biliary cirrhosis: Participation of cellular senescence and autophagy. International Journal of Hepatology vol. 2012 (2012), Article ID 452143, 9 pages, 2012. doi: 10.1155/2012/452143.
  • Zen Y, Nakanuma Y. IgG4 cholangiopathy. International Journal of Hepatology Vol. 2012 (2012), Article ID 472376, 6 pages, doi: 10.1155/2012/472376.
  • Harada K, Nakanuma Y. Cholangiopathy with respect to biliary innate immunity. International Journal of Hepatology Vol. 2012 (2012), Article ID 793569, 10 pages, doi: 10.1155/2012/793569.
  • Nakanuma Y. Tutorial review for understanding of cholangiopathy. International Journal of Hepatology vol. 2012(2012), Article ID 547840, 9 pages, doi: 10.1155/2012/547840.
  • Sato Y, Harada K, Sasaki M, Yasaka T, Nakanuma Y. Heat shock proteins 27 and 70 are potential biliary markers for the detection of cholangiocarcinoma. Am J Pathol 2012 Jan; 180(1): 123-30. (IF=4.522)
  • Hytiroglou P, Snover DC, Alves V, Balabaud C, Bhathal PS, Bioulac-Sage P, Crawford JM, Dhillon AP, Ferrell L, Guido M, Nakanuma Y, Paradis V, Quaglia A, Theise ND, Thung SN, Tsui WM, van Leeuwen DJ. Beyond “cirrhosis”: a proposal from the international liver pathology study group. Am J Clin Pathol 2012 Jan; 137(1): 5-9.(IF=2.881)
  • Takeshita Y, Takamura T, Inoue O, Okumura M, Kato K, Sunagozaka H, Arai K, Misu H, Nakamura M, Nakanuma Y, Kaneko S. Slowly progressive insulin-dependent diabetes in a patient with primary biliary cirrhosis with portal hypertension-type progression. Intern Med 2012; 51(1): 79-82. (IF=0.973)
  • Harada K, Shimoda S, Kimura Y, Sato Y, Ikeda H, Igarashi S, Ren XS, Sato H, Nakanuma Y. Significance of IgG4-positive cells in extrahepatic cholangiocarcinoma: Molecular mechanism of IgG4 reaction in cancer tissue. Hepatology 2012 Jul; 56(1): 157-64.(IF=12.003)
  • Sato Y, Ren XS, Harada K, Sasaki M, Morikawa H, Shiomi S, Honda M, Kaneko S, Nakanuma Y. Induction of elastin expression in vascular endothelial cells relates to hepatoportal sclerosis in idiopathic portal hypertension: possible link to serum anti-endothelial cell antibodies. Clin Exp Immunol 2012 Mar; 167(3): 532-42.(IF=3.409)
  • Sasaki M, Miyakoshi M, Sato Y, Nakanuma Y. A possible involvement of p62/sequestosome-1 in theprocess of biliary epithelial autophagy and senescence in primary biliary cirrhosis. Liver Int 2012 Mar; 32(3): 487-99.(IF=3.870)
  • Sasaki M, Miyakoshi M, Sato Y, Nakanuma Y. Autophagy may precede cellular senescence of bile ductular cells in ductular reaction in primary biliary cirrhosis. Dig Dis Sci 2012 Mar; 57(3): 660-6. (IF=2.260)
  • Harada K, Sato Y, Ikeda H, Maylee H, Igarashi S, Okamura A, Masuda S, Nakanuma Y. Clinicopathologic study of mixed adenoneuroendocrine carcinomas of hepatobiliary organs. Virchows Arch 2012 Mar; 460(3): 281-9.(IF=2.676)
  • Xu J, Igarashi S, Sasaki M, Matsubara T, Yoneda N, Kozaka K, Ikeda H, Kim J, Yu E, Matsui O, Nakanuma Y. Intrahepatic cholangiocarcinomas in cirrhosis are hypervascular in comparison with those in normal livers. Liver Int 2012 Aug; 32(7): 1156-64.(IF=3.870)
  • Ikeda H, Sato Y, Yoneda N, Harada K, Sasaki M, Kitamura S, Sudo Y, Ooi A, Nakanuma Y. α-Fetoproteinproducing gastric carcinoma and combined hepatocellular and cholangiocarcinoma show similar morphology but different histogenesis with respect to SALL4 expression. Hum Pathol 2012 Nov; 43(11): 1955-63.(IF=2.843)
  • Shimoda S, Tsuneyama K, Kikuchi K, Harada K, Nakanuma Y, Nakamura M, Ishibashi H, Hisamoto S, Niiro H, Leung PS, Ansari AA, Gershwin ME, Akashi K. The role of natural killer (NK) and NKT cells in the loss of tolerance in murine primary biliary cirrhosis. Clin Exp Immunol 2012 Jun; 168(3): 279-84.(IF=3.409)
  • Maylee H, Harada K, Igarashi S, Tohda G, Yamamoto M, Ren XS, Osawa T, Hasegawa Y, Takahashi N, Nakanuma Y. Case of telangiectatic/inflammatory hepatocellular adenoma arising in a patient with primary sclerosing cholangitis. Hepatol Res 2012 Jun; 42(6): 611-8.(IF=2.072)
  • Igarashi S, Matsubara T, Harada K, Ikeda H, Sato Y, Sasaki M, Matsui O, Nakanuma Y. Bile duct expression of pancreatic and duodenal homeobox 1 in perihilar cholangiocarcinogenesis. Histopathology 2012 Aug; 61(2): 266-76.(IF=2.857)
  • Kimura Y, Harada K, Nakanuma Y. Pathologic significance of immunoglobulin G4-positive plasma cells in extrahepatic cholangiocarcinoma. Hum Pathol 2012 Dec; 43(12): 2149-56.(IF=2.843)
  • Deshpande V, Zen Y, Chan JK, Yi EE, Sato Y, Yoshino T, Klöppel G, Heathcote JG, Khosroshahi A, Ferry JA, Aalberse RC, Bloch DB, Brugge WR, Bateman AC, Carruthers MN, Chari ST, Cheuk W, Cornell LD, Fernandez-Del Castillo C, Forcione DG, Hamilos DL, Kamisawa T, Kasashima S, Kawa S, Kawano M, Lauwers GY, Masaki Y, Nakanuma Y, Notohara K, Okazaki K, Ryu JK, Saeki T, Sahani DV, Smyrk TC, Stone JR, Takahira M, Webster GJ, Yamamoto M, Zamboni G, Umehara H, Stone JH. Consensus statement on the pathology of IgG4-related disease. Mod Pathol 2012 Sep; 25(9): 1181-92. (IF=5.253)
  • Yoneda N, Matsui O, Kitao A, Kita R, Kozaka K, Koda W, Kobayashi S, Gabata T, Ikeda H, Sato Y, Nakanuma Y. Hepatocyte transporter expression in FNH and FNH-like nodule: correlation with signal intensity on gadoxetic acid enhanced magnetic resonance images. Jpn J Radiol 2012 Jul; 30(6): 499-508.(IF=0.730)
  • Matsubara T, Sato Y, Sasaki M, Harada K, Nomoto K, Tsuneyama K, Nakamura K, Gabata T, Matsui O, Nakanuma Y. Immunohistochemical characteristics and malignant progression of hepatic cystic neoplasms in comparison with pancreatic counterparts. Hum Pathol 2012 Dec; 43(12): 2177-86. (IF=2.843)
  • Ohara H, Okazaki K, Tsubouchi H, Inui K, Kawa S, Kamisawa T, Tazuma S, Uchida K, Hirano K, Yoshida H, Nishino T, Ko SB, Mizuno N, Hamano H, Kanno A, Notohara K, Hasebe O, Nakazawa T, Nakanuma Y, Takikawa H. Clinical diagnostic criteria of IgG4-related sclerosing cholangitis 2012. J Hepatobiliary Pancreat Sci 2012 Sep; 19(5): 536-42.(IF=2.148)
  • Sasaki M, Yoneda N, Kitamura S, Sato Y, Nakanuma Y. A serum amyloid A-positive hepatocellular neoplasm arising in alcoholic cirrhosis: a previously unrecognized type of inflammatory hepatocellular tumor. Mod Pathol 2012 Dec; 25(12): 1584-93.(IF=5.253)
  • Yoneda N, Matsui O, Kitao A, Kozaka K, Gabata T, Sasaki M, Nakanuma Y, Murata K, Tani T. Betacatenin- activated hepatocellular adenoma showing hyperintensity on hepatobiliary-phase gadoxeticenhanced magnetic resonance imaging and overexpression of OATP8. Jpn J Radiol 2012 Nov; 30(9): 777-82.(IF=0.730)
  • Harada K, Nakanuma Y. Innate immunity in the pathogenesis of cholangiopathy: A recent update. Inflamm Allergy Drug Targets 2012; 11: 478-83.
  • Sasaki M, Nakanuma Y. Overview of hepatocellular adenoma in Japan. International Journal of Hepatology Vol. 2012 (2012), Article ID 648131, 6 pages doi: 10.1155/2012/648131.
  • Kita Y, Takamura T, Misu H, Ota T, Kurita S, Takeshita Y, Uno M, Nagata NM, Kato K, Ando H, Fujimura A, Hayashi K, Kimura T, Ni Y, Otoda T, Miyamoto K, Yoh Zen Y, Nakanuma Y, Kaneko S. Metformin prevents and reverses inflammation in a non-diabetic mouse model of nonalcoholic steatohepatitis. PLoS One 2012 Sep; 7(9): e43056.(IF=3.730)
  • Nakamura M, Nishida N, Kawashima M, Aiba Y, Tanaka A, Yasunami M, Nakamura H, Komori A, Nakamuta M, Zeniya M, Hashimoto E, Ohira H, Yamamoto K, Onji M, Kaneko S, Honda M, Yamagiwa S, Nakao K, Ichida T, Takikawa H, Seike M, Umemura T, Ueno Y, Sakisaka S, Kikuchi K, Ebinuma H, Yamashiki N, Tamura S, Sugawara Y, Mori A, Yagi S, Shirabe K, Taketomi A, Arai K, Monoe K, Ichikawa T, Taniai M, Miyake Y, Kumagi T, Abe M, Yoshizawa K, Joshita S, Shimoda S, Honda K, Takahashi H, Hirano K, Takeyama Y, Harada K, Migita K, Ito M, Yatsuhashi H, Fukushima N, Ota H, Komatsu T, Saoshiro T, Ishida J, Kouno H, Kouno H, Yagura M, Kobayashi M, Muro T, Masaki N, Hirata K, Watanabe Y, Nakamura Y, Shimada M, Hirashima N, Komeda T, Sugi K, Koga M, Ario K, Takesaki E, Maehara Y, Uemoto S, Kokudo N, Tsubouchi H, Mizokami M, Nakanuma Y, Tokunaga K, Ishibashi H. Genome-wide association study identifies TNFSF15 and POU2AF1 as susceptibility loci for primary biliary cirrhosis in the Japanese population. Am J Hum Genet 2012 Oct 5; 91(4): 721- 28.(IF=11.202)
  • Zen Y, Nakanuma Y, Portmann B. Immunoglobulin G4-related sclerosing cholangitis: pathologic features and histologic mimics. Semin Diagn Pathol 2012 Nov; 29(4): 205-11.(IF=1.615)
  • Nakanuma Y, Sato Y, Ikeda H, Harada K, Kobayashi M, Sano K, Uehara T, Yamamoto M, Ariizumi S, Nyun Park Y, Choi JH, Yu E. Intrahepatic cholangiocarcinoma with predominant “ductal plate malformation” pattern: A new subtype. Am J Surg Pathol 2012 Nov; 36(11): 1629-35.(IF=4.868)
  • Kitao A, Matsui O, Yoneda N, Kozaka K, Kobayashi S, Koda W, Gabata T, Yamashita T, Kaneko S, Nakanuma Y, Kita R, Arii S. Hypervascular hepatocellular carcinoma: Correlation between biologic features and signal intensity on gadoxetic acid-enhanced MR images. Radiology 2012 Dec; 265(3): 780-9.(IF=6.339)
  • Yoshikawa A, Nakada M, Ohtsuki S, Hayashi Y, Obuchi W, Sato Y, Ikeda C, Watanabe T, Kawahara Y, Hasegawa T, Sabit H, Kita D, Hayashi Y, Nakanuma Y, Terasaki T, Hamada JI. Recurrent anaplastic meningioma treated by sunitinib based on results from quantitative proteomics. Neuropathol Appl Neurobiol 2012 Feb; 38(1): 105-10.(IF=4.837)
  • Kasashima S, Kawashima A, Ozaki S, Nakanuma Y. Expression of 5α-reductase in apocrine carcinoma of the breast and its correlation with clinicopathological aggressiveness. Histopathology 2012 May; 60(6B): E51-7.(IF=2.857)
  • Nakanuma Y, Demetris AJ, Ueno Y, Quaglia A. Cholangiopathy: Genetics, Mechanism, and Pathology. International Journal of Hepatology Vol. 2012 (2012), Article ID 950713, 1 page, doi: 10.1155/2012/950713Editorial.
  • Nakanuma Y, Sato Y. Cystic and papillary neoplasm involving peribiliary glands: A biliary counterpart of branch-type intraductal papillary mucinous neoplasm? Hepatology 2012 Jun; 55(6): 2040-1.(IF=12.003)
  • Lim J.H, Zen Y, Nakanuma Y. Intraductal papillary neoplasm of the bile ducts : Reply. AJR Am J Roentgenol 2012; 198(6): W628.(IF=2.897)

英文著書・他

Chapter Contribution
  • Nakanuma Y, Zen Y, Portman BC. Diseases of the bile ducts. In: Burt AD, Portman BC, Ferrell LD, editors. MacSween’s Pathology of the Liver 6th ed., Churchill Livingstone, Edinburg, London, New York, Oxford, Philadelphia, St Louis, Sydney, Toronto, 2012, p.491-562.
  • Nakanuma Y, Sato Y, Harada K. Tissue culture correlational study of genetic cholangiopathy of autosomal recessive polycystic kidney disease (Chapter 18). In: Scott H. Randell, M. Leslie Fulcher, editors. Methods in Molecular Biology, Epithelial Cell Culture Protocols, Second Edition. Springer Science + Buisiness Media, 2012, p.303-18.

邦文論文・他

邦文論文
  • 佐々木 素子，中沼 安二. 胆・膵腫瘍の分子病理診断. 最新医学 2012; 3: 59-65.
  • 岡崎 和一，川 茂幸，乾 和郎，神澤 輝美，田妻 進，内田 一茂，平野 賢二，吉田 仁，西野 隆義， 洪 繁，水野 伸匡，濱野 英明，菅野 敦，能登原 憲司，長谷部 修，中沢 貴宏，中沼 安二，滝川 一， 坪内 博仁，大原 弘隆(委員長). ＜報告＞IgG4関連硬化性胆管炎臨床診断基準2012. 厚生労働省 IgG4関連全身硬化性疾患の診断法の確立と治療方法の開発に関する研究班. 厚生労働省難治性の肝 胆道疾患に関する調査研究班. 日本胆道学会. 胆道 2012; 26: 59-63.
  • 中沼 安二. 病理解剖マニュアル. 臓器肉眼所見の取り方：肝臓. 病理と臨床 2012; 30(臨時増刊号): 205-10.
  • 原田 憲一，中沼 安二. 病理像から見たIgG4硬化性胆管炎. 胆と膵 2012; 33: 485-90.
  • 中沼 安二，原田 憲一，佐藤 保則，丸藤 ちひろ，五十嵐 紗耶，池田 博子. 胆道癌幹細胞の同定 と臨床的意義－胆管周囲付属腺のインパクト－ . 肝胆膵 2012; 65: 95-105.
  • 原田 憲一，中沼 安二. 原発性硬化性胆管炎とIgG4関連硬化性胆管炎の病態と線維化の異同. 肝胆 膵 2012; 65: 343-9.
  • 中沼 安二，原田 憲一. 自己免疫性肝炎・原発性胆汁性肝硬変・硬化性胆管炎(IgG4関連硬化性胆管 炎を含む)の病理診断における最新の知見. 最新医学 2012; 8: 19-26.
  • 佐藤 保則，任 香善，中沼 安二. 胆道感染と胆管嚢状拡張のメカニズム. 日本腎臓学会誌 2012; 54: 538-42.
  • 北尾 梓，米田 憲秀，小坂 一斗，新村 理絵子，南 哲弥，龍 泰治，香田 渉，眞田 順一郎，小林 聡， 蒲田 敏文，荒井 邦明，山下太郎，山下 竜也，金子 周一，中沼 安二，松井 修. いわゆる良性腫瘍 のマリグナントプログレッション. 早期診断，癌化診断：最近のモダリティを用いて. 肝胆膵 2012; 65: 439-48.
  • 佐々木 素子，中沼 安二. 肝細胞腺腫の亜型と癌化の病理. 肝胆膵 2012; 65: 449-55.
  • 小林 聡，米田 憲秀，吉田 耕太郎，小坂 一斗，蒲田 敏文，松井 修，加村 毅，中沼 安二. アルコー ル多飲者にみられる多血清結節と癌化. 肝胆膵 2012; 65: 457-62.
  • 池田 博子，佐藤 保則，原田 憲一，松原 崇史，中沼 安二. 悪性ポテンシャルのある小型胆管病変と 癌化. 肝胆膵 2012; 65: 463-70.
  • 中西 喜嗣，大原 正範，中沼 安二，新田 健雄，平野 聡. 胆管付属腺に発生するIPNBと悪性化. 肝 胆膵 2012; 65: 495-502.
  • 佐藤 保則，中沼 安二. 胆管内上皮性腫瘍BilIN と癌化. 肝胆膵 2012; 65: 503-10.
  • 中沼 安二. 膵癌・胆道癌－診断・治療 Q&A. IPNB (胆管内乳頭状腫瘍)について詳しく教えてくだ さい. 膵・胆道癌FRONTIER 2012; 2: 34-7.
  • 中沼 安二，佐藤 保則，中西 喜嗣. 分枝型胆管内乳頭状腫瘍(IPNB, branch type)：その病理学的特 徴と発生・進展機序. 胆道 2012; 26: 592-8.
  • 石橋 大海，中沼 安二，上野 義之，江川 裕人，小池 和彦，小森 敦正，向坂 彰太郎，下田 慎治， 調 憲，銭谷 幹男，副島 雄二，竹山 康章，田中 篤，中牟田 誠，中村 稔，原田 憲一，福嶋 伸良， 前原 喜彦，森實 敏夫，坪内 博仁. 原発性胆汁性肝硬変(PBC) の診療ガイドライン(2012 年) 厚生 労働省難治性疾患克服研究事業「難治性の肝・胆道疾患に関する調査研究」班. 肝臓 2012; 53: 633-86.
  • 中沼 安二. 肝内胆管癌の腫瘍分類 －最近の展開，新たな提案を踏まえて－ . 日消誌 2012; 109: 1865-71.
  • 原田 憲一，中沼 安二. 原発性胆汁性肝硬変からの肝細胞癌. 肝胆膵 2012; 65: 965-70.
  • 佐々木 素子，中沼 安二. 肝細胞癌の病理. 肝胆膵 2012; 65: 1055-62.
  • 藤本 大裕，河野 史穂，寺田 卓郎，三井 毅，中沼 安二，山口 明夫. 非拡張型膵管胆管合流異常に 合併した胆嚢粘膜上皮内癌の1 例. 日本消化器外科学会雑誌 2012; 45: 1180-5.
  • 佐藤 保則，松原 崇史，角田 優子，中沼 安二. 膵癌の前癌病変. 外科 2012; 74: 462-7.
  • 中沼 安二，滝川 一，岡崎 和一. 自己免疫性肝胆膵疾患－最近の知見－座談会：肝胆膵領域におけ る自己免疫疾患の新展開. 最新医学 2012; 8: 7-18.
  • 中沼 安二，角谷 眞澄，高山 忠利，尾島 英知. いわゆる良性腫瘍のマリグナントプログレッション. 座談会. 肝胆膵2012; 65: 533-50.
その他
  • 石橋 大海, 中沼 安二, 坪内 博仁. 難治性の肝・胆道疾患に関する調査研究班 原発性胆汁性肝硬変 (PBC)診療ガイドラインMinds : 公益財団法人日本医療機能評価機構.
  • 中沼 安二. 学会スペシャル：第48 回日本胆道学会学術集会. 改訂作業が進む胆道癌診療ガイドライ ン，推奨の方向性をより明確化 [胆道学会2012]. 日経メディカルオンライン 2012.
  • 中沼 安二. 編集後記. 胆道 2012; 26(4): 654.