金沢大学医薬保健研究域医学系 人体病理学教室 (第2病理学教室)

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業績

お問い合わせ

〒920-8640
石川県金沢市宝町13-1

医局長 佐藤保則
Tel 076-265-2199
mail sato-ya@med.kanazawa-u.ac.jp

秘書 高野由紀子
Tel 076-265-2197
mail takanoy7@med.kanazawa-u.ac.jp

金沢大学附属病院

業績Results

2017年(平成29年)

英文論文

 ・Pathologidal findings of nonalcoholic steatohepatitis and nonalcoholic fatty liver disease.

      Sakamoto M, Tsujikawa H, Effendi K, Ojima H, Harada K, Zen Y, Kondo F, Nakano M,

      Kage M,  Sumida Y, Hashimoto E, Yamada G, Okanoue T, Koike K.

      Pathol Int. 2017 Jan;67(1):1-7     doi: 10.1111/pin.12485. No abstract available.

   ・Genome-wide association studies identify PRKCB as a novel genetic susceptibility locus for

      primary biliary cholangitis in the Japanese population.  Kawashima M, Hitomi Y, Aiba Y,

      Nishida N,Kojima K, kawai Y,   ... Harada K, et al.   Hum Mol Genet. 2017 Jan 5.

      pii:ddw406.  doi: 10.1093/hmg/ddw406.

    ・Mutational landscape combined hepatocellular carcinoma and cholangiocarcinoma, and its

       clinicopathological significance.  Sasaki M, Sato Y, Nakanuma Y. Histopathology 2017

       70,423-434    Doi:10.1111/his.13084

     ・Stress-induced cellular responses and cell death mechanisms during inflammatory

        cholangiopathies.  Sasaki M, Nakanuma Y.  Clinics and Research in Hepatology and

        Gastroenterology  2017(41):129-138

     ・Bile Acids and Deregulated cholangiocyte Autophagy in Primary Biliary Cholangitis.

        Sasaki M, Nakanuma Y.  Dig Dis   2017;35:210-216    DOI: 10.1159/000450913

     ・Expression and localization of sterile alpha motif domain containing 5 is associated with

        cell type and malignancy of biliary tree.  Yagai T, Matsui S, Harada K, Inagaki F, Saijou E,

        Miura Y, Nakanuma Y, Miyajima A, Tanaka M.   PLos One. 2017  7;12(4):e0175355.

        doi: 10.1371/journal.pone.0175355. eCollection 2017.

     ・Genetic analyses of isolated high-grade pancreatic intraepithelial neoplasia(HG-PanIN) 

        rebeal paucity of ations in TP53 and SMAD4.  Hosoda W, Chianchiano P, Griffin JF, 

        Pittman ME, Brosens LA, Noe M, Yu J, Shindo K, Suenaga M, Rezaee N, Yonescu R, 

        Ning Y, Alberos-Saavedra J, Yoshizawa N, Harada K, Yoshizawa A, Hanada K, Yonehara S, 

        Shimizu M, Uehara T,  Samra JS, Gill AJ, Wolfgang CL, Goggins MG, Hruban RH, Wood LD.

        J Pathol. 2017 Feb 11.  doi: 10.1002/path.4884.

      ・The PD-1/PD-L1 axis may be aberratly activated in occupational cholangiocarcinoma.

        Yasunori Sato, Masahiko Kinoshita, Shigekazu Takemura, Shogo Tanaka, Genya Hamano,

        Shoji Nakamori, Masahiro Fujikawa, Yasuhiko Sugawara, Takatsugu Yamamoto, 

        Akira Arimoto, Minako Yamamura, Motoko Sasaki, Kenichi Harada, Yasuni Nakanuma,

        and Shoji Kubo.  Pathol Int.  2017  67:163-170      doi: 10.1111/pin.12511

      ・Insulin-like growth factor Ⅱ mRNA-binding protein3(IMP3) is a marker that predicts

         presence of invasion in papillary biliary tumors. Motoko Sasaki, Yasunori Sato.

         Human Pathology  2017  62:152-159

      ・Rathke Cleft Cyst with Entirely Ossified Cyst Wall and Partially Solid Cyst Contest:

         A Case Report and Literature Review.   Yasuhiko Hayashi, Masahiro Oishi, Issei Fukui,

         Yasuo Sasagawa, Kenichi Harada, Mitsutoshi Nakada. World Neurosurgery   2017

         98:Pages 882.e15-882.e20

      ・Acute presentation of autoimmune hepatitis: a multicentre study with detailed histological

        evalution in a large cohort of patients.  Nguyen canh H, Harada K, Ouchi h, Sato y,

        Tsuneyama K, kage M, Nakano M, Yoshizawa K, Takahashi A, Abe M, Kang JH, Koike k,

        Inui a, Fujisawa T, Takaki A, Arinaga-Hino T, Torimura t, Suzuki Y, Fujiwara K, Zeniya M,

        Ohira H, Tanaka A, Takikawa H;  Intractable Liver and Biliary Diseases Study Group of

        Japan.  J Clin pathol.  2017 Apr 20.     pii:jclinpath-2016-204271  

        doi: 10.1136/jclinpath-2016-204271.

     ・The simultaneous inhibition of the mTOR and MAPK pathways with Gnetin-C induces

       apoptosis in acute myeloid leukemia.  J.luis espinoza, Mahmoud I.Elbadry, Masafumi

        Taniwaki, Kenichi Harada, Ly Quoc Trung, Noriharu Nakagawa, Akiyoshi Takami, Ken

        Ishiyama, Takuji Yamauchi, Katsuto Takenaka, Shinji Nakao.  Cancer Letters  2017

        400:127-136

      ・Safety, Tolerability, and preliminary Efficacy of the Anti-Fibrotic Small Molecule PRI-724,

         a CBP/β-catenin inhibitor, in Patients with Hepatitis C Virus-related Cirrhosis:

          A Single-Center, Open-Label, Dose Escalation Phase 1 Trial.    Kimura K, Ikoma A,

          Shibakawa M,Shimoda S, Harada K, Saio M, Imamura J, Osawa Y, Kimura M,

          Nishikawa K, Okusaka T, Morita S, Inoue K, Kanto T, Todaka K, nakanishi Y, Kohara M,

          Mizokami M.   E Bio Medicine   2017 Aug 19.   doi: 10.1016/j.ebion.2017.08.016

       ・Challenges and difficulties in pathological diagnosis of autoimmune hepatitis.

          Harada K, Hiep NC, Ohira H.    Hepatol Res.  2017  Sep;47(10): 963-971

           doi: 10.1111/hepr.12931

  ・Diagnostic sensitivity of cutoff values of IgG4-posotove plasma cell number and

         IgG4-positive/CD138-positive cell ratio in typical multiple lesions of patients with

         IgG4-related disease.   Mizushima i, Yamada K, Harada K, Matsui S, Saeki T, Kondo S,

         Takahira M, Waseda Y, Hamaguchi Y, Fujii H, Yamagishi M, Kawano M.

          Mod Rheumatol. 2017  22:1-7   doi:10.1080/14397595.2017.1332540.

      ・Gadoxetic acid-enhanced magnetic resonance imaging reflects co-activation of β-catenin

         and hepatocyte nuclear factor 4α in hepatocellular carcinoma.  Kitao A, Matsui O,

         Yoneda N, Kozaka K, Kobayashi S, Koda W, Minami T, Inoue D, Yoshida K, Yamashita T,

         Yamashita T, Kaneko S, Takamura H, ohta t, Ikeda H, Sato Y, Nakanuma Y, Harada K,

         Kita R, Gabata T.    Hepatol Res.  2017    doi: 10.1111/hepr.12911

      ・A case of ruptured hepatocellular carcinoma(HCC) in resolving non-alcoholic

         steatohepatitis associated with type 2 diabetes: Is early detection of diabetes-related

         HCC feasible?  Ikura Y, Tiniakos DG, Tanaka T, Harada K.  

         J Diabetes. 2017;9(3):311-313    doi: 10.1111/1753-0407.12493     Epub 2016 Nov 24

  ・Clinical features of cystatin A expression in patients with pancreatic ductal

         adenocarcinoma.  Komura t, Takabatake h, Harada K, Yamato M, miyazawa M,

         Yoshida K, Honda M, Wada T, Kitagawa H, Ohta T, Kaneko S, Sakai Y.

          Cancer Sci.  2017   doi:10.1111/cas.13396

  ・Sclerosing and abstructive cholangiopathy in biliary atresia: mechanisms and association

         with biliary innate immunity.   Kenichi Harada       Pediatr Surg Int  2017 

         DOI 10.1007/s00383-017-4154-8

  ・Clinicopathological Study of Autoimmune Hepatitis Cases That Were Difficult to

         Differentiate from Drug-Induced Liver Injury.    Tsutsui A, Harada K, Tsuneyama K,

         Senoh T, nagano T, Takeguchi K, Ando M, Nakamura S, Mizobuchi K, Kudo M. 

         Dig dis.  2017;35(6):506-514.     doi:10.1159/000480139.  Epub 2017 Oct 17.

      ・BRAF V600E, TERT promoter mutations and CDKN2A/B homozygous deletions are

         frequent in epithelioid glioblastomas: A histological and molecular analysis focusing on

        intratumoral heterogeneity.  Nakajima N, Nobusawa S, Nakata S, Nakada M, yamazaki T,

        Matsumura N, Harada K, matsuda H, Funata N, Nagai S, Nakamura H, Sasaki A, Akimoto J,

        Hirato J, Yokoo H.   Brain Pathol. 2017  Nob 4.  doi:10.1111/bpa.12572.

      ・Role for Neutrophil Extracellular Traps(NETs) and Platelet  Agguregation in Early

         Sepsos-induced Hepatic Dysfunction.  Sakurai K, Miyashita T, Okazaki M, Yamaguchi T,

         Ohbatake Y, Nakanuma S, Okamoto K, Sakai S, Kinoshita J, Makino I, Nakamura K,

         Hayashi H, Oyama K, Tajima H, Takamura H, Ninomiya I, Fushida S, Harada K,

         Harmon JW, Ohta T.  In Bivo. 2017  Nov-Dec; 31(6): 1051-1058

      ・Usefulness of laparoscopy and intraductal ultrasonography in a patient with isolated

         immunogloblin G4-related sclerosing cholangitis.   Ohno Y, Kumagi T, Imamura Y,

         Kuroda T, Koizumi M, Watanabe T, Yoshida O, Tokumoto Y, Takeshita E, Abe M,

         Harada K, Hiasa Y.  

         Clin J Gastroenterol.  2017 Nov 1     doi: 10.1007/s12328-017-0787-3

       

 

 

 

 

 

英文著書・分担執筆等

  ・Pathology of the Bile Duct    Editor Yasuni Nakanuma

        Chapter10   Immunopathology of Biliary Atresia   P121-137

        Kenichi Harada          Springer 2017  総ページ数:212ページ

  ・Pathology of the Bile Duct    Editor Yasuni Nakanuma

        Chapter4     Cellular Senescence and Biliary Disorders   P39-54

        Motoko Sasaki           Springer 2017  総ページ数:212ページ

  ・Pathology of the Bile Duct    Editor Yasuni Nakanuma

        Chapter14   Cystic and micropapillary Neoplasm of peribiliary Glands:

                          Its perspective to Cholangiocarcinogenesis      P177-188

        Yasunori Sato            Springer 2017 総ページ数:212ページ

     ・Biliary Diseases with Pancreatic Counterparts      Editor Yasuni Nakanuma

        Chapter3    IgG4-Related Sclerosing Cholangitis and Type1 Autoimmune Pancreatitis

         Kenichi Harada      NOVA  2017  総ページ:271ページ  P47-61

     ・Biliary Diseases with Pancreatic Counterparts      Editor Yasuni Nakanuma

        Chapter10    Mucinous cystic Neoplasm of the Liver and Pancreas     P199-215

         Motoko Sasaki       NOVA  2017  総ページ:271ページ   

  ・Biliary Diseases with Pancreatic Counterparts     Editor Yasuni Nakanuma

         Chapter6      Biliary Intraepithelial Neoplasia and Pancreatic Intraepithelial Neoplasia

         Yasunori Sato        NOVA  2017 総ページ:271ページ  P111-136

        

       

        

        

         

       

 

特別講義・講演

 ・原田 憲一

       教育講演「自己免疫性肝疾患のトピック」

       第125回日本消化器病学会北陸支部例会 第38回教育講演会

          (平成29年11月5日、石川県地場産業振興センター 金沢市)招待講演

    ・原田 憲一

       教育講演「自己免疫性肝炎の病理」

       第45回「Liver Disease Working Group」

          (平成29年11月9日、帝京大学医学部 東京都)招待講演

    ・原田 憲一

       基調講演「肝線維化の病態と治療戦略」

       第21回日本肝臓学会大会 JDDW2017

           (平成29年10月12日、福岡国際会議場 福岡市)招待講演