金沢大学医薬保健研究域医学系 人体病理学教室 (第2病理学教室)

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業績

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〒920-8640
石川県金沢市宝町13-1

医局長 佐藤保則
Tel 076-265-2199
mail sato-ya@med.kanazawa-u.ac.jp

秘書 高野由紀子
Tel 076-265-2197
mail takanoy7@med.kanazawa-u.ac.jp

金沢大学附属病院

業績Results

2013年(平成25年)

英文論文

  • Endo M, Yasui K, Zen Y, Gen Y, Zen K, Tsuji K, Dohi O, Mitsuyoshi H, Tanaka S, Taniwaki M, Nakanuma Y, Arii S, Yoshikawa T. Alterations of the SWI/SNF chromatin remodelling subunit-BRG1 and BRM in hepatocellular carcinoma. Liver Int 2013 Jan; 33(1): 105-17.(IF=3.870)
  • Sato Y, Nakanuma Y. Role of endothelial-mesenchymal transition in idiopathic portal hypertension. Histol Histopathol 2013 Feb; 28(2): 145-54.(IF=2.281)
  • Sasaki M, Miyakoshi M, Sato Y, Nakanuma Y. Increased expression of mitochondrial proteins associated with autophagy in biliary epithelial lesions in primary biliary cirrhosis. Liver Int 2013 Feb; 33(2): 312-20.(IF=3.870)
  • Harada K, Hsu M, Ikeda H, Zeniya M, Nakanuma Y. Application and validation of a new histologic staging and grading system for primary biliary cirrhosis. J Clin Gastroenterol 2013 Feb; 47(2): 174-81. (IF=3.203)
  • Kakuda Y, Harada K, Sawada-Kitamura S, Ikeda H, Sato Y, Sasaki M, Okafuji H, Mizukoshi E, Terasaki S, Ohta H, Kasashima S, Kawashima A, Kaizaki Y, Kaneko S, Nakanuma Y. Evaluation of a new histologic staging and grading system for primary biliary cirrhosis in comparison with classical systems. Hum Pathol 2013 Jun; 44(6): 1107-17.(IF=2.843)
  • Sato H, Nakanuma Y, Kozaka K, Sato Y, Ikeda H. Spread of hilar cholangiocarcinomas via peribiliary gland network: a hither-to-unrecognized route of periductal infiltration. Int J Clin Exp Pathol 2013; 6(2): 318-22.(IF=2.242)
  • Hsu M, Sasaki M, Igarashi S, Sato Y, Nakanuma Y. KRAS and GNAS mutations and p53 overexpression in biliary intraepithelial neoplasia and intrahepatic cholangiocarcinomas. Cancer 2013 May 1; 119(9): 1669-74.(IF=5.201)
  • Furubo S, Sato Y, Harada K, Nakanuma Y. Roles of myofibroblasts and Notch and Hedgehog signaling pathways in formation of intrahepatic bile duct lesions of the polycystic kidney rat. Pediatr Dev Pathol 2013 May/June; 16(3): 177-90.(IF=0.859)
  • Sasaki M, Matsubara T, Yoneda N, Nomoto K, Tsuneyama K, Sato Y, Nakanuma Y. Overexpression of enhancer of zeste homolog 2 and MUC1 may be related to malignant behaviour in intraductalpapillary neoplasm of the bile duct. Histopathology 2013 Feb; 62(3): 446-57.(IF=2.857)
  • Okamura A, Harada K, Nio M, Nakanuma Y. Participation of natural killer cells in the pathogenesis of bile duct lesions in biliary atresia. J Clin Pathol 2013 Feb; 66(2): 99-108.(IF=2.439)
  • Nozaki Y, Harada K, Sanzen T, Nakanuma Y. PPARγ ligand attenuates portal inflammation in the MRL-lpr mouse: a new strategy to restrain cholangiopathy in primary biliary cirrhosis. Med Mol Morphol 2013 Sep; 46(3): 153-9.(IF=1.171)
  • Harada K, Sato Y, Ikeda H, Hsu M, Igarashi S, Nakanuma Y. Notch1-Hes1 signalling axis in the tumourigenesis of biliary neuroendocrine tumours. J Clin Pathol 2013 May; 66(5): 386-91.(IF=2.439)
  • Hodo Y, Honda M, Tanaka A, Nomura Y, Arai K, Yamashita T, Sakai Y, Yamashita T, Mizukoshi E, Sakai A, Sasaki M, Nakanuma Y, Moriyama M, Kaneko S. Association of Interleukin 28B genotype and hepatocellular carcinoma recurrence in patients with chronic hepatitis C. Clin Cancer Res 2013 Apr 1; 19(7): 1827-37.(IF=7.837)
  • Sato Y, Harada K, Sasaki M, Nakanuma Y. Histological characteristics of biliary intraepithelial neoplasia-3 and intraepithelial spread of cholangiocarcinoma. Virchows Arch 2013 Apr; 462(4): 421-7. (IF=2.676)
  • Hall AR, Dhillon AP, Green AC, Ferrell L, Crawford JM, Alves V, Balabaud C, Bhathal P, Bioulac-Sage P, Guido M, Hytiroglou P, Nakanuma Y, Paradis V, Quaglia A, Snover D, Theise N, Thung S, Tsui W, van Leeuwen DJ. Hepatic steatosis estimated microscopically versus digital image analysis. Liver Int 2013 Jul; 33(6): 926-35.(IF=3.870)
  • Gandou C, Harada K, Sato Y, Igarashi S, Sasaki M, Ikeda H, Nakanuma Y. Hilar cholangiocarcinoma and pancreatic ductal adenocarcinoma share similar histopathologies, immunophenotypes, and development-related molecules. Hum Pathol 2013 May; 44(5): 811-21.(IF=2.843)
  • Okamura A, Harada K, Nio M, Nakanuma Y. Interleukin-32 production associated with biliary innate immunity and proinflammatory cytokines contributes to the pathogenesis of cholangitis in biliary atresia. Clin Exp Immunol 2013 Aug; 173(2): 268-75.(IF=3.409)
  • Harada K, Hirohara J, Ueno Y, Nakano T, Kakuda Y, Tsubouchi H, Ichida T, Nakanuma Y. Incidence of and risk factors for hepatocellular carcinoma in primary biliary cirrhosis: National data from Japan. Hepatology 2013 May; 57(5): 1942-9.(IF=12.003)
  • Matsuda A, Kuno A, Matsuzaki H, Kawamoto T, Shikanai T, Nakanuma Y, Yamamoto M, Ohkohchi N, Ikehara Y, Shoda J, Hirabayashi J, Narimatsu H. Glycoproteomics-based cancer marker discovery adopting dual enrichment with Wisteria floribunda agglutinin for high specific glyco-diagnosis of cholangiocarcinoma. J Proteomics 2013 Jun 24; 85: 1-11.(IF=4.088)
  • Egawa H, Nakanuma Y, Maehara Y, Uemoto S, Eguchi S, Sato Y, Shirabe K, Takatsuki M, Mori A, Yamamoto M, Tsubouchi H. Disease recurrence plays a minor role as a cause for retransplantation after living-donor liver transplantation for primary biliary cirrhosis: A multicenter study in Japan. Hepatol Res 2013 May; 43(5): 502-7.(IF=2.072)
  • Sato Y, Harada K, Sasaki M, Nakanuma Y. Clinicopathological significance of S100 protein expression in cholangiocarcinoma. J Gastroenterol Hepatol 2013; 28(8): 1422-29.(IF=3.325)
  • Sasaki M, Kondo F, Sawai Y, Imai Y, Kadowaki S, Sano K, Fukusato T, Matsui O, Nakanuma Y. Serum amyloid A-positive hepatocellular neoplasms in the resected livers from 3 patients with alcoholic cirrhosis. Histol Histopathol 2013; 28: 1499-505.(IF=2.281)
  • Onishi I, Kitagawa H, Harada K, Maruzen S, Sakai S, Makino I, Hayashi H, Nakagawara H, Tajima H,Takamura H, Tani T, Kayahara M, Ikeda H, Ohta T, Nakanuma Y. Intraductal papillary neoplasm of the bile duct accompanying biliary mixed adenoneuroendocrine carcinoma. World J Gastroenterol 2013 May 28; 19(20): 3161-4.(IF=2.547)
  • Harada K, Kakuda Y, Nakamura M, Shimoda S, Nakanuma Y. Clinicopathological significance of serum fractalkine in primary biliary cirrhosis. Dig Dis Sci 2013 Oct; 58(10): 3037-43.(IF=2.260)
  • Yoneda N, Matsui O, Kitao A, Kita R, Kozaka K, Koda W, Kobayashi S, Gabata T, Ikeda H, Nakanuma Y. Hypervascular hepatocellular carcinomas showing hyperintensity on hepatobiliary phase of gadoxetic acid-enhanced magnetic resonance imaging: a possible subtype with mature hepatocyte nature. Jpn J Radiol 2013 Jul; 31(7): 480-90.(IF=0.730)
  • Zen Y, Liberal R, Nakanuma Y, Heaton N, Portmann B. Possible involvement of CCL1-CCR8 interaction in lymphocytic recruitment in IgG4-related sclerosing cholangitis. J Hepatol 2013 Nov; 59(5): 1059-64.(IF=9.858)
  • Takamura H, Nakanuma S, Hayashi H, Tajima H, Kakinoki K, Sakai S, Makino I, Nakagawara H, Miyashita T, Okamoto K, Nakamura K, Oyama K, Inokuchi M, Ninomiya I, Kitagawa H, Fushida S, Fujimura T, Ohnishi I, Kayahara M, Tani T, Arai K, Yamashita T, Yamashita T, Kitamura H, Ikeda H, Kaneko S, Nakanuma Y, Matsui O, Ohta T. Evaluation of eligibility criteria in living donor liver transplantation for hepatocellular carcinoma by α -SMA-positive cancer-associated fibroblasts. Oncol Rep 2013 Oct; 30(4): 1561-74.(IF=2.297)
  • Hsu M, Sasaki M, Igarashi S, Sato Y, Nakanuma Y. Erratum: KRAS and GNAS mutations and p53 overexpression in biliary intraepithelial neoplasia and intrahepatic cholangiocarcinomas. Volume 119, Issue 13, 1 July 2013, Page 2513.
  • Kubota K, Nakanuma Y, Kondo F, Hachiya H, Miyazaki M, Nagino M, Yamamoto M, Isayama H, Tabata M, Kinoshita H, Kamisawa T, Inui K. Clinicopathological features and prognosis of mucinproducing bile duct tumor and mucinous cystic tumor of the liver: a multi-institutional study by the Japan Biliary Association. J Hepatobiliary Pancreat Sci 2013 Aug 1.(IF=2.148)
  • Sugimoto K, Moriyasu F, Kono S, Sasaki M, Nakanuma Y, Imai Y. A case of mucinous cystic neoplasm of the liver: description of Sonazoid-enhanced ultrasound imaging and histopathologic findings. Journal of Medical Ultrasonics 2013 Jul; 40(3): 243-50.(IF=0.635)
  • Sasaki M, Ikeda T, Hatanaka KC, Nakanuma Y. Hyperplastic hepatocellular nodule with localized hemangiomatosis - A hither-to unrecognized type of hypervascular hepatic lesion. Hepatol Res. 2013 Aug 8. doi: 10.1111/hepr.12218. [Epub ahead of print].(IF=2.072)
  • Ikeda H, Harada K, Sato Y, Sasaki M, Yoneda N, Kitamura S, Sudo Y, Ooi A, Nakanuma Y. Clinicopathologic significance of combined hepatocellular-cholangiocarcinoma with stem cell subtype components with reference to the expression of putative stem cell markers. Am J Clin Pathol 2013 Sep; 140(3): 329-40.(IF=2.881)
  • Aiba Y, Harada K, Komori A, Ito M, Shimoda S, Nakamura H, Nagaoka S, Abiru S, Migita K, Ishibashi H, Nakanuma Y, Nishida N, Kawashima M, Tokunaga K, Yatsuhashi H, Nakamura M. Systemic and local expression levels of TNF-like ligand 1A and its decoy receptor 3 are increased in primary biliary cirrhosis. Liver Int 2013 Aug 2. doi: 10.1111/liv.12296. [Epub ahead of print].(IF=3.870)
  • Nakanuma Y. A letter to the editor. Primary biliary cirrhosis: Is there still a place for histological evaluation? Clin Res Hepatol Gastroenterol 2013 Sep 9. [Epub ahead of print].(IF=1.348)
  • Igarashi S, Sato Y, Ren XS, Harada K, Sasaki M, Nakanuma Y. Participation of peribiliary glands inbiliary tract pathophysiologies. World J Hepatol 2013 Aug 27; 5(8): 425-32.
  • Tani J, Miyoshi H, Sasaki M, Nakanuma Y, Nomura T, Yoneyama H, Morishita A, Kobara H, Hirohito M, Himoto T, Masaki T. Multiple Hypervascular FNH-like Lesions in a Patient with No History of Alcohol Abuse or Chronic Liver Disease. Intern Med 2013; 52(19): 2225-30.(IF=0.973)
  • Sato H, Sato Y, Harada K, Sasaki M, Hirano K, Nakanuma Y. Metachronous intracystic and intraductal papillary neoplasms of the biliary tree. World J Gastroenterol 2013 Sep 28; 19(36): 6125- 6126.(IF=2.547)
  • Sasaki M, Miyakoshi M, Sato Y, Nakanuma Y. Chemokine-chemokine receptor CCL2-CCR2 and CX3CL1-CX3CR1 axis may play a role in the aggravated inflammation in primary biliary cirrhosis. Dig Dis Sci 2013 Nov 2. [Epub ahead of print].(IF=2.260)
  • Harada K, Kakuda Y, Sato Y, Ikeda H, Shimoda S, Yamamoto Y, Inoue H, Ohta H, Kasashima S, Kawashima A, Nakanuma Y. Alteration of energy metabolism in the pathogenesis of bile duct lesions in primary biliary cirrhosis. J Clin Pathol 2013 Nov 29. doi: 10.1136/jclinpath-2013-201815. (IF=2.439)
  • Sasaki M, Matsubara T, Nitta T, Sato Y, Nakanuma Y. GNAS and KRAS mutations are common in intraductal papillary neoplasms of the bile duct. PLoS One 2013 Dec; 8(12): e81706.(IF=3.730)
  • Kasashima S, Kawashima A, Endo M, Matsumoto Y, Kasashima F, Zen Y, Nakanuma Y. A clinicopathologic study of immunoglobulin G4-related disease of the femoral and popliteal arteries in the spectrum of immunoglobulin G4-related periarteritis. J Vasc Surg 2013 Mar; 57(3): 816-22. (IF=2.879)
  • Uema N, Ooshio T, Harada K, Naito M, Naka K, Hoshii T, Tadokoro Y, Ohta K, Ali MA, Katano M, Soga T, Nakanuma Y, Okuda A, Hirao A. Abundant nucleostemin expression supports the undifferentiated properties of germ cell tumors. Am J Pathol 2013 Aug; 183(2): 592-603.(IF=4.522)
  • Yamada K, Hamaguchi Y, Saeki T, Yagi K, Ito N, Kakuchi Y, Yamagishi M, Takehara K, Nakanuma Y, Kawano M. Investigations of IgG4-related disease involving the skin. Mod Rheumatol 2013 Sep; 23(5): 986-93.(IF=1.716)
  • Furubo S, Sato Y, Harada K, Nakanuma Y. Pediatric and Developmental Pathology (Cover). Pediatr Dev Pathol 2013 May-June(3).

英文著書・他

Proceedings and Others
  • Nakanuma Y. Diagnostic procedures for biliary intraepithelial neoplasm. The 2013 International Diagnostic Pathology Course in Tokyo, 2013. p.7-10.

邦文論文・他

邦文論文
  • 廣原 淳子,仲野 俊成,關 壽人,岡崎 和一,中沼 安二,坪内 博仁. 原発性胆汁性肝硬変(PBC)全国調査にみる本邦PBCの病態と予後の変遷. 日消誌 2013; 110: 8-15.
  • 原田 憲一,中沼 安二. 原発性胆汁性肝硬変の新しい病期分類・活動度分類. 病理と臨床 2013; 31:210-12.
  • 中沼 安二,佐々木 素子,佐藤 保則. 早期胆道癌(胆嚢と胆管)の分子病理. 肝胆膵 2013; 66171-80.
  • 有井 滋樹,真口 宏介,糸井 隆夫,中沼 安二. 胆膵癌の早期診断フロントライン. 座談会:胆膵癌の早期診断. 肝胆膵 2013; 66: 351-71.
  • 佐々木 素子,中沼 安二. K-ras. 臨床検査 2013; 57: 256-61.
  • 佐藤 保則,中沼 安二. 胆管内乳頭腫瘍(IPNB)と胆管上皮腫瘍性病変(BiIIN)の診断と意義. 病理と臨床 2013; 31: 237-44.
  • 佐藤 保則,中沼 安二. 肝前駆細胞の肝細胞,胆管細胞,膵腺房への分化. 肝胆膵 2013; 66: 587-92.
  • 佐々木 素子,中沼 安二. 胆道ステム細胞. 肝胆膵 2013; 66: 593-603.
  • 松原 崇史,佐藤 保則,五十嵐 紗耶,小坂 一斗,小林 聡,蒲田 敏文,松井 修,中沼 安二. 胆管周囲嚢胞 -膵との関連性に注目して- . 肝胆膵 2013; 66: 653-60.
  • 原田 憲一,佐藤 保則,中沼 安二. 先天的非腫瘍性嚢胞性疾患:多嚢胞性肝疾患,Caroli病,前腸性肝嚢胞. 肝胆膵 2013; 66: 671-9.
  • 中沼 安二,佐藤 保則. 肝外胆管癌と膵管癌. 肝胆膵 2013; 66: 681-9.
  • 中西 喜嗣,中沼 安二,河上 洋,松本 譲,新田 健雄,佐藤 保則,平野 聡. IPMNとIPNB:前腸由来臓器に発生する乳頭状腫瘍の疾患理解. 肝胆膵 2013; 66: 691-700.
  • 中沼 安二,川口 義弥,吉富 秀幸,千葉 哲博. 前腸系ステム細胞. 座談会:肝胆膵 2013; 66: 715-30.
  • 佐々木 素子,中沼 安二. 肝炎ウイルスと肝臓癌 病理と臨床 2013; 31: 110-5.
  • 中沼 安二,佐藤 保則. 胆管・胆嚢の組織学的基礎-胆管での粘液産生と胆管周囲付属腺について- .胆と膵 2013; 34: 347-52.
  • 松原 崇史,小坂 一斗,蒲田 敏文,松井 修,小林 聡,北川 裕久,太田 哲生,大坪 公士郎,北村星子,池田 博子,中沼 安二. 著明な粘液産生を示したIPNBの1 例. 胆と膵 2013; 34: 403-12.
  • 中沼 安二,原田 憲一,佐藤 保則. 原発性硬化性胆管炎と潰瘍性大腸炎はなぜ合併するのか. 分子消化器病 2013 6; 10: 17-22.
  • 中沼 安二,佐々木 素子,佐藤 保則,原田 憲一. 胆道癌の病理診断. 消化器外科 2013; 36: 1097-108.
  • 久保 正二,竹村 茂一,坂田 親治,中沼 安二,圓藤 吟史. 胆道癌の集団発生. 消化器外科 2013; 36:1121-25.
  • 原田 憲一,中沼 安二. 胆道癌とIgG4関連病態. 肝胆膵 2013; 67(3): 415-24.
  • 中沼 安二,浜野 英明,滝川 一,井上 大. IgG4 と肝胆膵. 座談会. 肝胆膵 2013; 67(3): 443-58.
  • 佐々木 素子,中沼 安二. 肝癌類似病変の分子病理学的診断:新しい動向. 日本の肝細胞腺腫とアルコール性肝硬変に発生するserum amyloid A陽性肝細胞性腫瘍. THE LIVER CANCER JOURNAL2013; 5(3): 184-8.
  • 角田 優子,斉川 邦和,松下 信之,原田 憲一,中沼 安二. オルセイン染色の実態調査結果と標準化への試み. 肝臓 2013; 54(10): 716-9.
  • 佐藤 保則,中沼 安二. 肝内結石症の胆道発癌-病理学的立場から. 胆と膵 2013; 34(11): 1145-52.
その他
  • 中沼 安二. 自然免疫から,胆管疾患の成り立ちを考える.「社会への情報発信」日本病理学会(ホームページ).