Publications

Year　2024 2023　2022　2021　2020　2019　2018　2017　2016　2015　2014

2024

  1. Osanai H, Kozaka K, Yoneda N, Yoshida K, Kitao A, Gabata T, Harada K, Makino I, Kobayashi S. Reactive lymphoid hyperplasia of the liver: A case report featuring characteristic nodular and perinodular enhancement. Radiology Case Reports. 2024, 19(5), 1998-2003. doi:10.1016/j.radcr.2024.02.029.

2022　2021　2020　2019　2018　2017　2016　2015　2014

2023

  1. Calderaro J, Ghaffari L, Zeng Q, Maille P, Favre L, Pujals A, Klein C, Bazille C, Heij L, Uguen A, Luedde T, Di T, Beaufrère A, Chatain A, Gastineau D, Nguyen C, Nguyen-Canh H, Thi K, Gnemmi V, Graham R, Charlotte F, Wendum D, Vij M, Allende D, Aucejo F, Diaz A, Rivière B, Herrero A, Evert K, Calvisi D, Augustin J, Leow W, Leung H, Boleslawski E, Rela M, François A, Cha A, Forner A, Reig M, Allaire M, Scatton O, Chatelain D, Boulagnon-Rombi C, Sturm N, Menahem B, Frouin E, Tougeron D, Tournigand C, Kempf E, Kim H, Ningarhari M, Michalak-Provost S, Gopal P, Brustia R, Vibert E, Schulze K, Rüther D, Weidemann S, Rhaiem R, Pawlotsky J, Zhang X, Luciani A, Mulé S, Laurent A, Amaddeo G, Regnault H, De M, Sempoux C, Navale P, Westerhoff M, Lo R, Bednarsch J, Gouw A, Guettier C, Lequoy M, Harada K, Sripongpun P, Wetwittayaklang P, Loménie N, Tantipisit J, Kaewdech A, Shen J, Paradis V, Caruso S, Kather J. Deep learning-based phenotyping reclassifies combined hepatocellular-cholangiocarcinoma. Nat Commun. 2023, 14(1), 8290. doi:10.1038/s41467-023-43749-3.
  2. Kasashima S, Kawashima A, Kurose N, Ozaki S, Kasashima F, Matsumoto Y, Takemura H, Ikeda H, Harada K. Disordered Balance of T‐Cell Subsets in Arterial Tertiary Lymphoid Organs in Immunoglobulin G4–Related Vascular Disease. JAHA. 2023, 12(24), e030356. doi:10.1161/JAHA.123.030356.
  3. Ozaki K, Yoneda N, Harada K, Ikeno H, Takahashi M, Kaizaki Y, Maeda K, Higuchi S, Takata K, Gabata T. A case of focal nodular hyperplasia-like lesion presenting unusual signal intensity on the hepatobiliary phase of gadoxetic acid-enhanced magnetic resonance image. Radiol Case Rep. 2023, 18(9), 3093-3100. doi:10.1016/j.radcr.2023.05.049.
  4. Chayama K, Hiramatsu A, Shima T, Itoh Y, Yamaguchi K, Nakajima T, Hoshikawa K, Kawamura Y, Akuta N, Ito K, Kawanaka M, Sakamoto M, Harada K, Goto Y, Nakayama T, Kumada H, Okanoue T. Impact of fibrosis on liver‐related event incidence in nonalcoholic fatty liver disease: A multicenter observational study. Hepatol Res. 2023, NANA, hepr.13950. doi:10.1111/hepr.13950.
  5. Sugita H, Nakanuma S, Gabata R, Tokoro T, Takei R, Okazaki M, Kato K, Takada S, Makino I, Kozaka K, Harada K, Yagi S. Clinicopathological features of cholangiolocarcinoma and impact of tumor heterogeneity on prognosis: A retrospective study in a single institution. NA. 2023, NANA, NA. .
  6. Abuduwaili H, Kamoshita K, Ishii K, Takahashi K, Abuduyimiti T, Qifang L, Isobe Y, Goto H, Nakano Y, Takeshita Y, Takayama H, Harada K, Takamura T. Selenoprotein P deficiency protects against immobilization-induced muscle atrophy by suppressing atrophy-related E3 ubiquitin ligases. Am J Physiol Endocrinol Metab. 2023, 324(6), E542-E552. doi:10.1152/ajpendo.00270.2022.
  7. Terashima T, Yamashita T, Takabatake H, Nakanuma S, Kinoshita J, Yagi S, Mizukoshi E, Harada K, Fushida S, Kaneko S. Successful second conversion surgery after trastuzumab deruxtecan for recurrent HER2-positive gastric cancer. Clin J Gastroenterol. 2023, 16(3), 330-335. doi:10.1007/s12328-023-01764-3.
  8. Ouchi H, Mizutani Y, Yoshimura K, Sato Y, Kimura K, Haruyama Y, Harada K. Anti-inflammatory and antifibrotic effects of CBP/β-catenin inhibitor for hepatocytes: small molecular inhibitor, OP-724 possibly improves liver function. Med Mol Morphol. 2023, 56(2), 94-105. doi:10.1007/s00795-022-00343-8.
  9. Li Q, Ishii K, Kamoshita K, Takahashi K, Abuduwaili H, Takayama H, Galicia-Medina C, Tanida R, Ko O, Gafiyatullina G, Yao X, Abuduyimiti T, Hamazaki J, Goto H, Nakano Y, Takeshita Y, Harada K, Murata S, Takamura T. PAC1 Deficiency Protects Obese Male Mice From Immobilization-Induced Muscle Atrophy by Suppressing FoxO–Atrogene Axis. Endocrinology. 2023, 164(6), bqad065. doi:10.1210/endocr/bqad065.
  10. Kitao A, Matsui O, Zhang Y, Ogi T, Nakada S, Sato Y, Harada K, Yoneda N, Kozaka K, Inoue D, Yoshida K, Koda W, Yamashita T, Yamashita T, Kaneko S, Kobayashi S, Gabata T. Dynamic CT and Gadoxetic Acid-enhanced MRI Characteristics of P53-mutated Hepatocellular Carcinoma. Radiology. 2023, 306(2), e220531. doi:10.1148/radiol.220531.
  11. Inaba Y, Hashiuchi E, Watanabe H, Kimura K, Oshima Y, Tsuchiya K, Murai S, Takahashi C, Matsumoto M, Kitajima S, Yamamoto Y, Honda M, Asahara S, Ravnskjaer K, Horike S, Kaneko S, Kasuga M, Nakano H, Harada K, Inoue H. The transcription factor ATF3 switches cell death from apoptosis to necroptosis in hepatic steatosis in male mice. Nat Commun. 2023, 14(1), 167. doi:10.1038/s41467-023-35804-w.
  12. Yoshimura K, Tamano Y, Nguyen C, Zihan L, Le T, Sato Y, Terashima T, Shimoda S, Harada K. A novel pathologic marker, indoleamine 2,3-dioxygenase 1, for the cholangiopathy of immune checkpoint inhibitors-induced immune mediated hepatotoxicity as adverse events and the prediction of additional ursodeoxycholic acid treatment. Med Mol Morphol. 2023, 56(2), 106-115. doi:10.1007/s00795-022-00344-7.

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2022

  1. Yamaguchi K, Shima T, Mitsumoto Y, Seko Y, Umemura A, Itoh Y, Nakajima A, Kaneko S, Harada K, Watkins T, Okanoue T. Fibro-Scope V1.0.1: an artificial intelligence/neural network system for staging of nonalcoholic steatohepatitis. Hepatol Int. 2022, 17(3), 573-583. doi:10.1007/s12072-022-10454-0.
  2. Yamamura M, Sato Y, Takahashi K, Canh H, Li Z, Hosomichi K, Tajima A, Terada T, Nakanuma Y, Harada K. A case of hepatic small vessel neoplasm without previously reported hotspot mutation of alpha subfamily of G proteins. Hum Pathol: Case Rep. 2022, 29NA, 300660. doi:10.1016/j.hpr.2022.300660.
  3. Takahashi K, Ofuji K, Nosaka T, Naito T, Matsuda H, Ohtani M, Hiramatsu K, Harada K, Naiki H, Nakamoto Y. Elderly onset congenital hepatic fibrosis with portal hypertension diagnosed after recurrent cholangitis: a case report. Clin J Gastroenterol. 2022, 15(3), 611-616. doi:10.1007/s12328-022-01620-w.
  4. Kimura K, Kanto T, Shimoda S, Harada K, Kimura M, Nishikawa K, Imamura J, Ogawa E, Saio M, Ikura Y, Okusaka T, Inoue K, Ishikawa T, Ieiri I, Kishimoto J, Todaka K, Kamisawa T. Safety, tolerability, and anti-fibrotic efficacy of the CBP/β-catenin inhibitor PRI-724 in patients with hepatitis C and B virus-induced liver cirrhosis: An investigator-initiated, open-label, non-randomised, multicentre, phase 1/2a study. EBioMedicine. 2022, 80NA, 104069. doi:10.1016/j.ebiom.2022.104069.
  5. Kubo S, Shinkawa H, Asaoka Y, Ioka T, Igaki H, Izumi N, Itoi T, Unno M, Ohtsuka M, Okusaka T, Kadoya M, Kudo M, Kumada T, Kokudo N, Sakamoto M, Sakamoto Y, Sakurai H, Takayama T, Nakashima O, Nagata Y, Hatano E, Harada K, Murakami T, Yamamoto M. Liver Cancer Study Group of Japan Clinical Practice Guidelines for Intrahepatic Cholangiocarcinoma. Liver Cancer. 2022, 11(4), 290-314. doi:10.1159/000522403.

2024 2023　2020　2019　2018　2017　2016　2015　2014

2021

  1. Sheng J, Kohno S, Okada N, Okahashi N, Teranishi K, Matsuda F, Shimizu H, Linn P, Nagatani N, Yamamura M, Harada K, Horike S, Inoue H, Yano S, Kumar S, Kitajima S, Ajioka I, Takahashi C. Treatment of Retinoblastoma 1–Intact Hepatocellular Carcinoma With Cyclin‐Dependent Kinase 4/6 Inhibitor Combination Therapy. Hepatol. 2021, 74(4), 1971-1993. doi:10.1002/hep.31872.
  2. Yamamura M, Sato Y, Takahashi K, Nguyen C, Li Z, Kimoto T, Terasaki S, Harada K. Hilar cholangiocarcinoma with extensive immunoglobulin G4 reaction. Int J Clin Exp Pathol. 2021, 14(9), 987-992. .
  3. Kasashima S, Kawashima A, Kurose N, Ozaki S, Ikeda H, Harada K. Regional disturbance of the distribution of T regulatory cells and T helper cells associated with irregular-shaped germinal centers in immunoglobulin G4-related sialadenitis. Virchows Arch. 2021, 479(6), 1221-1232. doi:10.1007/s00428-021-03187-2.
  4. Okanoue T, Sakamoto M, Harada K, Inagaki M, Totsuka N, Hashimoto G, Kumada H. Efficacy and safety of apararenone (MT‐3995) in patients with nonalcoholic steatohepatitis: A randomized controlled study. Hepatol Res. 2021, 51(9), 943-956. doi:10.1111/hepr.13695.
  5. Ishida K, Seki A, Kawaguchi K, Nasti A, Yamato M, Inui H, Komura T, Yamashita T, Arai K, Yamashita T, Mizukoshi E, Honda M, Wada T, Harada K, Kaneko S, Sakai Y. Restorative effect of adipose tissue-derived stem cells on impaired hepatocytes through Notch signaling in non-alcoholic steatohepatitis mice. Stem Cell Res. 2021, 54NA, 102425. doi:10.1016/j.scr.2021.102425.
  6. Takahashi K, Sato Y, Yamamura M, Nakada S, Tamano Y, Sasaki M, Harada K. Notch‐Hes1 signaling activation in Caroli disease and polycystic liver disease. Pathol Int. 2021, 71(8), 521-529. doi:10.1111/pin.13130.
  7. Nakajima K, Mizokami A, Matsuyama H, Ichikawa T, Kaneko G, Takahashi S, Shiina H, Horikoshi H, Hashine K, Sugiyama Y, Miyao T, Kamiyama M, Harada K, Ito A, PROSTAT‐BSI I. Prognosis of patients with prostate cancer and bone metastasis from the Japanese Prostatic Cancer Registry of Standard Hormonal and Chemotherapy Using Bone Scan Index cohort study. Int J of Urology. 2021, 28(9), 955-963. doi:10.1111/iju.14614.
  8. Okanoue T, Shima T, Mitsumoto Y, Umemura A, Yamaguchi K, Itoh Y, Yoneda M, Nakajima A, Mizukoshi E, Kaneko S, Harada K. Novel artificial intelligent/neural network system for staging of nonalcoholic steatohepatitis. Hepatol Res. 2021, 51(10), 1044-1057. doi:10.1111/hepr.13681.
  9. Nguyen C, Takahashi K, Yamamura M, Li Z, Sato Y, Yoshimura K, Kozaka K, Tanaka M, Nakanuma Y, Harada K. Diversity in cell differentiation, histology, phenotype and vasculature of mass‐forming intrahepatic cholangiocarcinomas. Histopathology. 2021, 79(5), 731-750. doi:10.1111/his.14417.
  10. Komine R, Kojima M, Ishi G, Kudo M, Sugimoto M, Kobayashi S, Takahashi S, Konishi M, Kobayashi T, Akimoto T, Murakami A, Sasaki M, Tanaka M, Matsuzaki A, Ohike N, Uchida K, Sugiyama T, Hirabayashi K, Tajiri T, Ishida K, Kai K, Omori Y, Notohara K, Yamaguchi H, Matsuda Y, Naito Y, Fukumura Y, Hamada Y, Mihara Y, Masugi Y, Gotohda N, Harada K, Fukushima N, Furukawa T. Recognition and pathological features of periampullary region adenocarcinoma with an indeterminable origin. Cancer Med. 2021, 10(11), 3499-3510. doi:10.1002/cam4.3809.
  11. Yaegashi H, Kato Y, Nohara T, Izumi K, Kadono Y, Miyagi T, Nakashima T, Yoshimura K, Sato Y, Harada K, Mizokami A. Histiocytic sarcoma following combination chemotherapy for primary mediastinal germ cell tumor: a diagnostic dilemma. Int Canc Conf J. 2021, 10(2), 144-148. doi:10.1007/s13691-020-00467-7.
  12. Sakai Y, Fukunishi S, Takamura M, Kawaguchi K, Inoue O, Usui S, Takashima S, Seki A, Asai A, Tsuchimoto Y, Nasti A, Bich H, Imai Y, Yoshimura K, Murayama T, Yamashita T, Arai K, Yamashita T, Mizukoshi E, Honda M, Wada T, Harada K, Higuchi K, Kaneko S. Clinical trial of autologous adipose tissue-derived regenerative (stem) cells therapy for exploration of its safety and efficacy. Regen Ther. 2021, 18NA, 97-101. doi:10.1016/j.reth.2021.04.003.
  13. Toyohara T, Nakazawa T, Zakharia K, Shimizu S, Miyabe K, Harada K, Notohara K, Yamada T, Hayashi K, Naitoh I, Hayashi K, Kataoka H. IgG4-related Sclerosing Cholangitis Complicated with Cholangiocarcinoma and Detected by Forkhead Box P3 Immunohistochemical Staining. Intern Med. 2021, 60(6), 859-866. doi:10.2169/internalmedicine.5920-20.
  14. Takakusagi S, Yokoyama Y, Kizawa K, Marubashi K, Kosone T, Sato K, Kakizaki S, Harada K, Takagi H, Uraoka T. Successfully Treated Case of Cholangiolocellular Carcinoma with a Poor Hepatic Functional Reserve Reporting with Various Imaging Findings. Intern Med. 2021, 60(6), 873-881. doi:10.2169/internalmedicine.5891-20.
  15. Wang G, Tanaka A, Zhao H, Jia J, Ma X, Harada K, Wang F, Wei L, Wang Q, Sun Y, Hong Y, Rao H, Efe C, Lau G, Payawal D, Gani R, Lindor K, Jafri W, Omata M, Sarin S. The Asian Pacific Association for the Study of the Liver clinical practice guidance: the diagnosis and management of patients with autoimmune hepatitis. Hepatol Int. 2021, 15(2), 223-257. doi:10.1007/s12072-021-10170-1.
  16. Hasan N, Nagata N, Morishige J, Islam M, Jing Z, Harada K, Mieda M, Ono M, Fujiwara H, Daikoku T, Fujiwara T, Maida Y, Ota T, Shimba S, Kaneko S, Fujimura A, Ando H. Brown adipocyte-specific knockout of Bmal1 causes mild but significant thermogenesis impairment in mice. Mol Metab. 2021, 49NA, 101202. doi:10.1016/j.molmet.2021.101202.
  17. Okanoue T, Shima T, Mitsumoto Y, Umemura A, Yamaguchi K, Itoh Y, Yoneda M, Nakajima A, Mizukoshi E, Kaneko S, Harada K. Artificial intelligence/neural network system for the screening of nonalcoholic fatty liver disease and nonalcoholic steatohepatitis. Hepatol Res. 2021, 51(5), 554-569. doi:10.1111/hepr.13628.
  18. Yaegashi H, Kato Y, Nohara T, Izumi K, Kadono Y, Miyagi T, Nakashima T, Yoshimura K, Sato Y, Harada K, Mizokami A. Histiocytic sarcoma following combination chemotherapy for primary mediastinal germ cell tumor: a diagnostic dilemma. Int Canc Conf J. 2021, 10(2), 144-148. doi:10.1007/s13691-020-00467-7.
  19. Nogami A, Saito S, Hasegawa H, Yoneda M, Harada K, Fujikawa H. Lymphoepithelioma-like cholangiocarcinoma with Epstein–Barr virus infection treated by radiofrequency ablation. Clin J Gastroenterol. 2021, 14(2), 638-644. doi:10.1007/s12328-020-01303-4.
  20. Kobayashi M, Matsumoto Y, Ohya M, Harada K, Kanno H. Histologic and Immunohistochemical Evaluation of Infiltrating Inflammatory Cells in Kawasaki Disease Arteritis Lesions. Appl Immunohistochem Mol Morphol. 2021, 29(1), 62-67. doi:10.1097/PAI.0000000000000860.

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2020

2019

  1. Yamamura M, Sato Y, Takahashi K, Sasaki M, Harada K. The cyclin‑dependent kinase pathway involving CDK1 is a potential therapeutic target for cholangiocarcinoma. Oncol Rep. 2019, NANA, NA. doi:10.3892/or.2019.7405.
  2. Nanashima A, Imamura N, Hiyoshi M, Hamada T, Yano K, Wada T, Kawakami H, Ban T, Kubota Y, Sato Y, Harada K. Planned limited resection of the extrahepatic bile duct in a case of intraductal papillary neoplasm of the bile duct based on preoperative examinations. Clin J Gastroenterol. 2019, 13(2), 233-239. doi:10.1007/s12328-019-01049-8.
  3. Zaimoku R, Miyashita T, Tajima H, Takamura H, Harashima A, Munesue S, Yamamoto Y, Ninomiya I, Fushida S, Harada K. Monitoring of Heat Shock Response and Phenotypic Changes in Hepatocellular Carcinoma After Heat Treatment. Anticancer Res. 2019, 39(10), 5393-5401. doi:10.21873/anticanres.13733.
  4. Terziroli B, Mieli-Vergani G, Vergani D, Vierling J, Adams D, Alpini G, Banales J, Beuers U, Björnsson E, Bowlus C, Carbone M, Chazouillères O, Dalekos G, De G, Harada K, Hirschfield G, Invernizzi P, Jones D, Krawitt E, Lanzavecchia A, Lian Z, Ma X, Manns M, Mavilio D, Quigley E, Sallusto F, Shimoda S, Strazzabosco M, Swain M, Tanaka A, Trauner M, Tsuneyama K, Zigmond E, Gershwin M. The challenges of primary biliary cholangitis: What is new and what needs to be done. J Autoimmun. 2019, 105NA, 102328. doi:10.1016/j.jaut.2019.102328.
  5. Seike T, Komura T, Shimizu Y, Omura H, Kumai T, Kagaya T, Ohta H, Kawashima A, Harada K, Kaneko S, Unoura M. A case of chronic pancreatitis exacerbation associated with pancreatic arteriovenous malformation: a case report and literature review. Clin J Gastroenterol. 2019, 12(2), 135-141. doi:10.1007/s12328-018-0901-1.
  6. Nakagawa R, Hiep N, Ouchi H, Sato Y, Harada K. Expression of fatty-acid-binding protein 5 in intrahepatic and extrahepatic cholangiocarcinoma: the possibility of different energy metabolisms in anatomical location. Med Mol Morphol. 2019, 53(1), 42-49. doi:10.1007/s00795-019-00230-9.
  7. Yoshida M, Zoshima T, Hara S, Mizushima I, Fujii H, Yamada K, Sato Y, Harada K, Kawano M. A Long-term Survival after Surgical Treatment for Atypical Aortic Coarctation Complicating Takayasu Arteritis with Inactive Disease at the Diagnosis: An Appropriately Treated Autopsy Case. Intern Med. 2019, 58(15), 2241-2246. doi:10.2169/internalmedicine.2483-18.
  8. Yan W, Wang X, Liu T, Chen L, Han L, Xu J, Jin G, Harada K, Lin Z, Ren X. Expression of endoplasmic reticulum oxidoreductase 1-α in cholangiocarcinoma tissues and its effects on the proliferation and migration of cholangiocarcinoma cells. Cancer Manag Res. 2019, 11NA, 6727-6739. doi:10.2147/CMAR.S188746.
  9. Amano N, Sato S, Murata A, Tsuzura H, Tomishima K, Sato S, Matsumoto K, Shimada Y, Iijima K, Harada K, Genda T. A case of primary biliary cholangitis overlapping with type 2 autoimmune hepatitis. Clin J Gastroenterol. 2019, 13(1), 79-82. doi:10.1007/s12328-019-01017-2.
  10. Horita S, Fujii H, Mizushima I, Fujisawa Y, Hara S, Yamada K, Inoue D, Nakajima K, Harada K, Kawano M. A case of IgG4-related tubulointerstitial nephritis and membranous glomerulonephritis during the clinical course of gastric cancer: Imaging features of IgG4-related kidney disease. Mod Rheumatol. 2019, 29(3), 542-546. doi:10.1080/14397595.2016.1245238.
  11. Tamai S, Kinoshita M, Sabit H, Furuta T, Miyashita K, Yoshimura K, Homma T, Harada K, Nakada M. Case of metastatic glioblastoma with primitive neuronal component to the lung. Neuropathol. 2019, 39(3), 218-223. doi:10.1111/neup.12553.
  12. Yamada K, Mizukoshi E, Seike T, Horii R, Terashima T, Iida N, Kitahara M, Sunagozaka H, Arai K, Yamashita T, Honda M, Takamura T, Harada K, Kaneko S. Serum C16:1n7/C16:0 ratio as a diagnostic marker for non‐alcoholic steatohepatitis. J of Gastro and Hepatol. 2019, 34(10), 1829-1835. doi:10.1111/jgh.14654.

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2018

  1. Seike T, Komura T, Shimizu Y, Omura H, Kumai T, Kagaya T, Ohta H, Kawashima A, Harada K, Kaneko S, Unoura M. A Young Man with Non-alcoholic Steatohepatitis and Serum Anti-mitochondrial Antibody Positivity. Intern Med. 2018, 57(21), 3093-3097. doi:10.2169/internalmedicine.0405-17.
  2. Aiba Y, Harada K, Ito M, Suematsu T, Aishima S, Hitomi Y, Nishida N, Kawashima M, Takatsuki M, Eguchi S, Shimoda S, Nakamura H, Komori A, Abiru S, Nagaoka S, Migita K, Yatsuhashi H, Tokunaga K, Nakamura M. Increased expression and altered localization of cathepsin Z are associated with progression to jaundice stage in primary biliary cholangitis. Sci Rep. 2018, 8(1), 11808. doi:10.1038/s41598-018-30146-w.
  3. Miura Y, Matsui S, Miyata N, Harada K, Kikkawa Y, Ohmuraya M, Araki K, Tsurusaki S, Okochi H, Goda N, Miyajima A, Tanaka M. Differential expression of Lutheran/BCAM regulates biliary tissue remodeling in ductular reaction during liver regeneration. Elife. 2018, 7NA, e36572. doi:10.7554/eLife.36572.
  4. Sato Y, Yamamura M, Sasaki M, Harada K. Blockade of Hedgehog Signaling Attenuates Biliary Cystogenesis in the Polycystic Kidney (PCK) Rat. Am J Pathol. 2018, 188(10), 2251-2263. doi:10.1016/j.ajpath.2018.06.014.
  5. Itoh Y, Seko Y, Shima T, Nakajima T, Mizuno K, Kawamura Y, Akuta N, Ito K, Kawanaka M, Hiramatsu A, Sakamoto M, Harada K, Goto Y, Nakayama T, Kumada H, Okanoue T. Accuracy of non‐invasive scoring systems for diagnosing non‐alcoholic steatohepatitis‐related fibrosis: Multicenter validation study. Hepatol Res. 2018, 48(13), 1099-1107. doi:10.1111/hepr.13226.
  6. Matsui S, Harada K, Miyata N, Okochi H, Miyajima A, Tanaka M. Characterization of Peribiliary Gland–Constituting Cells Based on Differential Expression of Trophoblast Cell Surface Protein 2 in Biliary Tract. Am J Pathol. 2018, 188(9), 2059-2073. doi:10.1016/j.ajpath.2018.05.016.
  7. Shimizu Y, Komura T, Seike T, Omura H, Kumai T, Kagaya T, Ohta H, Kawashima A, Harada K, Kaneko S, Unoura M. A case of an elderly female with diffuse hepatic hemangiomatosis complicated with multiple organic dysfunction and Kasabach–Merritt syndrome. Clin J Gastroenterol. 2018, 11(5), 411-416. doi:10.1007/s12328-018-0871-3.
  8. Nishida N, Aiba Y, Hitomi Y, Kawashima M, Kojima K, Kawai Y, Ueno K, Nakamura H, Yamashiki N, Tanaka T, Tamura S, Mori A, Yagi S, Soejima Y, Yoshizumi T, Takatsuki M, Tanaka A, Harada K, Shimoda S, Komori A, Eguchi S, Maehara Y, Uemoto S, Kokudo N, Nagasaki M, Tokunaga K, Nakamura M. NELFCD and CTSZ loci are associated with jaundice-stage progression in primary biliary cholangitis in the Japanese population. Sci Rep. 2018, 8(1), 8071. doi:10.1038/s41598-018-26369-6.
  9. Mizushima I, Yamada K, Harada K, Matsui S, Saeki T, Kondo S, Takahira M, Waseda Y, Hamaguchi Y, Fujii H, Yamagishi M, Kawano M. Diagnostic sensitivity of cutoff values of IgG4-positive plasma cell number and IgG4-positive/CD138-positive cell ratio in typical multiple lesions of patients with IgG4-related disease. Mod Rheumatol. 2018, 28(2), 293-299. doi:10.1080/14397595.2017.1332540.
  10. Tadokoro Y, Hoshii T, Yamazaki S, Eto K, Ema H, Kobayashi M, Ueno M, Ohta K, Arai Y, Hara E, Harada K, Oshima M, Oshima H, Arai F, Yoshimura A, Nakauchi H, Hirao A. Spred1 Safeguards Hematopoietic Homeostasis against Diet-Induced Systemic Stress. Cell Stem Cell. 2018, 22(5), 713-725.e8. doi:10.1016/j.stem.2018.04.002.
  11. Espinoza J, Elbadry M, Chonabayashi K, Yoshida Y, Katagiri T, Harada K, Nakagawa N, Zaimoku Y, Imi T, Takamatsu H, Ozawa T, Maruyama H, Hassanein H, Khalifa A, Takenaka K, Akashi K, Hamana H, Kishi H, Akatsuka Y, Nakao S. Hematopoiesis by iPSC-derived hematopoietic stem cells of aplastic anemia that escape cytotoxic T-cell attack. Blood Adv. 2018, 2(4), 390-400. doi:10.1182/bloodadvances.2017013342.
  12. The J, Joshita S, Yoshizawa K, Umemura T, Ohira H, Takahashi A, Harada K, Hiep N, Tsuneyama K, Kage M, Nakano M, Kang J, Koike K, Zeniya M, Yasunaka T, Takaki A, Torimura T, Abe M, Yokosuka O, Tanaka A, Takikawa H. Clinical features of autoimmune hepatitis with acute presentation: a Japanese nationwide survey. J Gastroenterol. 2018, 53(9), 1079-1088. doi:10.1007/s00535-018-1444-4.
  13. Inoue K, Okubo T, Kato T, Shimamura K, Sugita T, Kubota M, Kanaya K, Yamachika D, Sato M, Inoue D, Harada K, Kawano M. IgG4-related stomach muscle lesion with a renal pseudotumor and multiple renal rim-like lesions: A rare manifestation of IgG4-related disease. Mod Rheumatol. 2018, 28(1), 188-192. doi:10.3109/14397595.2015.1081743.

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2017

  1. Ozaki K, Harada K, Yamamoto T, Aoyagi H, Kaizaki Y, Yoshikawa J. Unclassified hepatocellular adenoma in a middle-aged woman with glucose intolerance. Clin J Gastroenterol. 2017, 11(1), 75-82. doi:10.1007/s12328-017-0788-2.
  2. Sakurai K, Miyashita T, Okazaki M, Yamaguchi T, Ohbatake Y, Nakanuma S, Okamoto K, Sakai S, Kinoshita J, Makino I, Nakamura K, Hayashi H, Oyama K, Tajima H, Takamura H, Ninomiya I, Fushida S, Harada K, Harmon J, Ohta T. Role for Neutrophil Extracellular Traps (NETs) and Platelet Aggregation in Early Sepsis-induced Hepatic Dysfunction. IV. 2017, 31(6), 1051-1058. doi:10.21873/invivo.11169.
  3. Nakajima N, Nobusawa S, Nakata S, Nakada M, Yamazaki T, Matsumura N, Harada K, Matsuda H, Funata N, Nagai S, Nakamura H, Sasaki A, Akimoto J, Hirato J, Yokoo H. BRAF V600E, TERT promoter mutations and CDKN2A/B homozygous deletions are frequent in epithelioid glioblastomas: a histological and molecular analysis focusing on intratumoral heterogeneity. Brain Pathol. 2017, 28(5), 663-673. doi:10.1111/bpa.12572.
  4. Ohno Y, Kumagi T, Imamura Y, Kuroda T, Koizumi M, Watanabe T, Yoshida O, Tokumoto Y, Takeshita E, Abe M, Harada K, Hiasa Y. Usefulness of laparoscopy and intraductal ultrasonography in a patient with isolated immunoglobulin G4-related sclerosing cholangitis. Clin J Gastroenterol. 2017, 11(1), 62-68. doi:10.1007/s12328-017-0787-3.
  5. Tsutsui A, Harada K, Tsuneyama K, Senoh T, Nagano T, Takaguchi K, Ando M, Nakamura S, Mizobuchi K, Kudo M. Clinicopathological Study of Autoimmune Hepatitis Cases That Were Difficult to Differentiate from Drug-Induced Liver Injury. Dig Dis. 2017, 35(6), 506-514. doi:10.1159/000480139.
  6. Harada K. Sclerosing and obstructive cholangiopathy in biliary atresia: mechanisms and association with biliary innate immunity. Pediatr Surg Int. 2017, 33(12), 1243-1248. doi:10.1007/s00383-017-4154-8.
  7. Komura T, Takabatake H, Harada K, Yamato M, Miyazawa M, Yoshida K, Honda M, Wada T, Kitagawa H, Ohta T, Kaneko S, Sakai Y. Clinical features of cystatin A expression in patients with pancreatic ductal adenocarcinoma. Cancer Sci. 2017, 108(11), 2122-2129. doi:10.1111/cas.13396.
  8. Kimura K, Ikoma A, Shibakawa M, Shimoda S, Harada K, Saio M, Imamura J, Osawa Y, Kimura M, Nishikawa K, Okusaka T, Morita S, Inoue K, Kanto T, Todaka K, Nakanishi Y, Kohara M, Mizokami M. Safety, Tolerability, and Preliminary Efficacy of the Anti-Fibrotic Small Molecule PRI-724, a CBP/β-Catenin Inhibitor, in Patients with Hepatitis C Virus-related Cirrhosis: A Single-Center, Open-Label, Dose Escalation Phase 1 Trial. EBioMedicine. 2017, 23NA, 79-87. doi:10.1016/j.ebiom.2017.08.016.
  9. Harada K, Hiep N, Ohira H. Challenges and difficulties in pathological diagnosis of autoimmune hepatitis: Pathology of AIH. Hepatol Res. 2017, 47(10), 963-971. doi:10.1111/hepr.12931.
  10. Kitao A, Matsui O, Yoneda N, Kozaka K, Kobayashi S, Koda W, Minami T, Inoue D, Yoshida K, Yamashita T, Yamashita T, Kaneko S, Takamura H, Ohta T, Ikeda H, Sato Y, Nakanuma Y, Harada K, Kita R, Gabata T. Gadoxetic acid-enhanced magnetic resonance imaging reflects co-activation of β-catenin and hepatocyte nuclear factor 4α in hepatocellular carcinoma: β-Catenin and HNF4α activation in HCC and MRI. Hepatol Res. 2017, 48(2), 205-216. doi:10.1111/hepr.12911.
  11. Nguyen C, Harada K, Ouchi H, Sato Y, Tsuneyama K, Kage M, Nakano M, Yoshizawa K, Takahashi A, Abe M, Kang J, Koike K, Inui A, Fujisawa T, Takaki A, Arinaga-Hino T, Torimura T, Suzuki Y, Fujiwara K, Zeniya M, Ohira H, Tanaka A, Takikawa H. Acute presentation of autoimmune hepatitis: a multicentre study with detailed histological evaluation in a large cohort of patients. J Clin Pathol. 2017, 70(11), 961-969. doi:10.1136/jclinpath-2016-204271.
  12. Espinoza J, Elbadry M, Taniwaki M, Harada K, Trung L, Nakagawa N, Takami A, Ishiyama K, Yamauchi T, Takenaka K, Nakao S. The simultaneous inhibition of the mTOR and MAPK pathways with Gnetin-C induces apoptosis in acute myeloid leukemia. Cancer Lett. 2017, 400NA, 127-136. doi:10.1016/j.canlet.2017.04.027.
  13. Yagai T, Matsui S, Harada K, Inagaki F, Saijou E, Miura Y, Nakanuma Y, Miyajima A, Tanaka M. Expression and localization of sterile alpha motif domain containing 5 is associated with cell type and malignancy of biliary tree. PLoS ONE. 2017, 12(4), e0175355. doi:10.1371/journal.pone.0175355.
  14. Hosoda W, Chianchiano P, Griffin J, Pittman M, Brosens L, Noë M, Yu J, Shindo K, Suenaga M, Rezaee N, Yonescu R, Ning Y, Albores‐Saavedra J, Yoshizawa N, Harada K, Yoshizawa A, Hanada K, Yonehara S, Shimizu M, Uehara T, Samra J, Gill A, Wolfgang C, Goggins M, Hruban R, Wood L. Genetic analyses of isolated high‐grade pancreatic intraepithelial neoplasia (HG‐PanIN) reveal paucity of alterations in TP53 and SMAD4. J Pathol. 2017, 242(1), 16-23. doi:10.1002/path.4884.
  15. Sato Y, Kinoshita M, Takemura S, Tanaka S, Hamano G, Nakamori S, Fujikawa M, Sugawara Y, Yamamoto T, Arimoto A, Yamamura M, Sasaki M, Harada K, Nakanuma Y, Kubo S. The PD-1/PD-L1 axis may be aberrantly activated in occupational cholangiocarcinoma: PD-1/PD-L1 in cholangiocarcinoma. Pathol Int. 2017, 67(3), 163-170. doi:10.1111/pin.12511.
  16. Kawashima M, Hitomi Y, Aiba Y, Nishida N, Kojima K, Kawai Y, Nakamura H, Tanaka A, Zeniya M, Hashimoto E, Ohira H, Yamamoto K, Abe M, Nakao K, Yamagiwa S, Kaneko S, Honda M, Umemura T, Ichida T, Seike M, Sakisaka S, Harada M, Yokosuka O, Ueno Y, Senju M, Kanda T, Shibata H, Himoto T, Murata K, Miyake Y, Ebinuma H, Taniai M, Joshita S, Nikami T, Ota H, Kouno H, Kouno H, Nakamuta M, Fukushima N, Kohjima M, Komatsu T, Komeda T, Ohara Y, Muro T, Yamashita T, Yoshizawa K, Nakamura Y, Shimada M, Hirashima N, Sugi K, Ario K, Takesaki E, Naganuma A, Mano H, Yamashita H, Matsushita K, Yamauchi K, Makita F, Nishimura H, Furuta K, Takahashi N, Kikuchi M, Masaki N, Tanaka T, Tamura S, Mori A, Yagi S, Shirabe K, Komori A, Migita K, Ito M, Nagaoka S, Abiru S, Yatsuhashi H, Yasunami M, Shimoda S, Harada K, Egawa H, Maehara Y, Uemoto S, Kokudo N, Takikawa H, Ishibashi H, Chayama K, Mizokami M, Nagasaki M, Tokunaga K, Nakamura M. Genome-wide association studies identify PRKCB as a novel genetic susceptibility locus for primary biliary cholangitis in the Japanese population. Hum Mol Genet. 2017, NANA, ddw406. doi:10.1093/hmg/ddw406.

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2016

  • Klionsky et al. Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy. 2016; 12(1): 1-222. doi:10.1080/15548627.2015.1100356.
  • Nakanuma Yasuni, Kakuda Yuko, Uesaka Katsuhiko, Miyata Takashi, Yamamoto Yusuke, Fukumura Yuki, Sato Yasunori, Sasaki Motoko, Harada Kenichi, Takase Masaru.
    Characterization of intraductal papillary neoplasm of bile duct with respect to histopathologic similarities to pancreatic intraductal papillary mucinous neoplasm. Hum Pathol. 2016; 51NA: 103-113. doi:10.1016/j.humpath.2015.12.022.
  • Zoshima Takeshi, Yamada Kazunori, Hara Satoshi, Mizushima Ichiro, Yamagishi Masakazu, Harada Kenichi, Sato Yasuharu, Kawano Mitsuhiro.
    Multicentric Castleman Disease With Tubulointerstitial Nephritis Mimicking IgG4-related Disease: Two Case Reports. Am J Surg Pathol. 2016; 40(4): 495-501. doi:10.1097/PAS.0000000000000575.
  • Sasaki Motoko, Nakanuma Yasuni.
    New concept: cellular senescence in pathophysiology of cholangiocarcinoma. Expert Rev Gastroenterol Hepatol. 2016; 10(5): 625-638. doi:10.1586/17474124.2016.1133291.
  • Hara Satoshi, Kawano Mitsuhiro, Mizushima Ichiro, Harada Kenichi, Takata Takuma, Saeki Takako, Ubara Yoshifumi, Sato Yasuharu, Nagata Michio.
    Distribution and components of interstitial inflammation and fibrosis in IgG4-related kidney disease: analysis of autopsy specimens. Hum Pathol. 2016; 55NA: 164-173. doi:10.1016/j.humpath.2016.05.010.
  • Ozaki Kumi, Harada Kenichi, Terayama Noboru, Matsui Osamu, Saitoh Satoshi, Tomimaru Yoshito, Fujii Takeshi, Gabata Toshifumi.
    Hepatocyte nuclear factor 1α-inactivated hepatocellular adenomas exhibit high 18 F-fludeoxyglucose uptake associated with glucose-6-phosphate transporter inactivation. BJR. 2016; 89(1063): 20160265. doi:10.1259/bjr.20160265.
  • Sasaki Motoko, Nitta Takeo, Sato Yasunori, Nakanuma Yasuni.
    Loss of ARID1A Expression Presents a Novel Pathway of Carcinogenesis in Biliary Carcinomas. Am J Clin Pathol. 2016; 145(6): 815-825. doi:10.1093/ajcp/aqw071.
  • Nguyen Canh Hiep, Harada Kenichi.
    Adult bile duct strictures: differentiating benign biliary stenosis from cholangiocarcinoma. Med Mol Morphol. 2016; 49(4): 189-202. doi:10.1007/s00795-016-0143-6.
  • Kim Soo Ki, Kim Soo Ryang, Imoto Susumu, Kim Chi Wan, Matsuoka Toshiyuki, Sasaki Motoko, Nakashima Osamu, Kumabe Tsutomu, Hayashi Yoshitake.
    Confluent hepatic fibrosis in alcohol liver cirrhosis with elevated pivkaii value – usefulness of immunostaining for EZH2 and p16 INK4a in differentiating it from cholangiolocellular carcinoma – Confluent hepatic fibrosis. Pathol. Int.. 2016; 66(9): 543-545. doi:10.1111/pin.12435.
  • Nakanuma Yasuni, Ishizu Yoji, Zen Yoh, Harada Kenichi, Umemura Takeji.
    Histopathology of IgG4-Related Autoimmune Hepatitis and IgG4-Related Hepatopathy in IgG4-Related Disease. Semin Liver Dis. 2016; 36(03): 229-241. doi:10.1055/s-0036-1584320.
  • Hisamoto Satomi, Shimoda Shinji, Harada Kenichi, Iwasaka Sho, Onohara Shinya, Chong Yong, Nakamura Minoru, Bekki Yuki, Yoshizumi Tomoharu, Ikegami Toru, Maehara Yoshihiko, He Xiao-Song, Gershwin M. Eric, Akashi Koichi.
    Hydrophobic bile acids suppress expression of AE2 in biliary epithelial cells and induce bile duct inflammation in primary biliary cholangitis. J Autoimmun. 2016; 75NA: 150-160. doi:10.1016/j.jaut.2016.08.006.
  • Hara Satoshi, Kawano Mitsuhiro, Mizushima Ichiro, Yamada Kazunori, Fujita Kentaro, Harada Kenichi, Matsumura Masami, Yamagishi Masakazu, Sato Yasuharu, Yamaguchi Yutaka, Nakanuma Yasuni, Nagata Michio.
    A condition closely mimicking IgG4-related disease despite the absence of serum IgG4 elevation and IgG4-positive plasma cell infiltration. Mod Rheumatol. 2016; 26(5): 784-789. doi:10.3109/14397595.2014.916836.
  • Sasaki Motoko, Nakanuma Yasuni.
    Stress-induced cellular responses and cell death mechanisms during inflammatory cholangiopathies. Clin Res Hepatol Gastroenterol. 2016; 41(2): 129-138. doi:10.1016/j.clinre.2016.08.002.
  • Sasaki Motoko, Sato Yasunori, Nakanuma Yasuni.
    Mutational landscape of combined hepatocellular carcinoma and cholangiocarcinoma, and its clinicopathological significance. Histopathology. 2016; 70(3): 423-434. doi:10.1111/his.13084.
  • Kim Soo Ki, Kim Soo Ryang, Imoto Susumu, Kim Chi Wan, Matsuoka Toshiyuki, Nakashima Osamu, Sasaki Motoko, Kumabe Tsutomu, Kudo Masatoshi, Fukusato Toshio, Kondo Fukuo.
    Bile duct adenoma in patient with chronic hepatitis C: As a benign neoplasm by pathological and imaging studies. Pathol. Int.. 2016; 66(11): 640-642. doi:10.1111/pin.12457.
  • Yoneda Norihide, Matsui Osamu, Kitao Azusa, Kozaka Kazuto, Kobayashi Satoshi, Sasaki Motoko, Yoshida Kotaro, Inoue Dai, Minami Tetsuya, Gabata Toshifumi.
    Benign Hepatocellular Nodules: Hepatobiliary Phase of Gadoxetic Acid–enhanced MR Imaging Based on Molecular Background. RadioGraphics. 2016; 36(7): 2010-2027. doi:10.1148/rg.2016160037.
  • Ikura Yoshihiro, Tiniakos Dina G., Tanaka Takeshi, Harada Kenichi.
    A case of ruptured hepatocellular carcinoma (HCC) in resolving non-alcoholic steatohepatitis associated with type 2 diabetes: Is early detection of diabetes-related HCC feasible?. J Diabetes. 2016; 9(3): 311-313. doi:10.1111/1753-0407.12493.
  • Hayashi Yasuhiko, Oishi Masahiro, Fukui Issei, Sasagawa Yasuo, Harada Ken-ichi, Nakada Mitsutoshi.
    Rathke Cleft Cyst with Entirely Ossified Cyst Wall and Partially Solid Cyst Content: A Case Report and Literature Review. World Neurosurg. 2016; 98NA: 882.e15-882.e20. doi:10.1016/j.wneu.2016.10.052.
  • Nakanuma Yasuni, Uchida Tsuneyuki, Sato Yasunori, Uesaka Katsuhiko.
    An S100P-positive biliary epithelial field is a preinvasive intraepithelial neoplasm in nodular-sclerosing cholangiocarcinoma. Hum Pathol. 2016; 60NA: 46-57. doi:10.1016/j.humpath.2016.10.003.
  • Working Group, Association of Pathologists* for Guidebook of NASH and NAFLD 2015: The Japan Society of Hepatology.
    Pathological Findings of NASH and NAFLD: for Guidebook of NASH and NAFLD, 2015: The Japan Society of Hepatology. Hepatol Res. 2016; 47(1): 3-10. doi:10.1111/hepr.12847.
  • Sakamoto Michiie, Tsujikawa Hanako, Effendi Kathryn, Ojima Hidenori, Harada Kenichi, Zen Yoh, Kondo Fukuo, Nakano Masayuki, Kage Masayoshi, Sumida Yoshio, Hashimoto Etsuko, Yamada Gotaro, Okanoue Takeshi, Koike Kazuhiko.
    Pathological findings of nonalcoholic steatohepatitis and nonalcoholic fatty liver disease. Pathol. Int.. 2016; 67(1): 1-7. doi:10.1111/pin.12485.

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2015

  • Sasaki Motoko, Yoshimura-Miyakoshi Masami, Sato Yasunori, Nakanuma Yasuni.
    A possible involvement of endoplasmic reticulum stress in biliary epithelial autophagy and senescence in primary biliary cirrhosis. J Gastroenterol. 2015; 50(9): 984-995. doi:10.1007/s00535-014-1033-0.
  • Sasaki Motoko, Nakanuma Yasuni.
    Cellular senescence in biliary pathology: Special emphasis on expression of a polycomb group protein EZH2 and a senescent marker p16INK4a in bile ductular tumors and lesions. Histol. Histopathol.. 2015; NA(30): 267-275. doi:10.14670/HH-30.267.
  • Sato Yasunori, Harada Kenichi, Sasaki Motoko, Nakanuma Yasuni.
    Altered intrahepatic microcirculation of idiopathic portal hypertension in relation to glutamine synthetase expression: Altered microcirculation in IPH. Hepatol Res. 2015; 45(13): 1323-1330. doi:10.1111/hepr.12506.
  • Komura Takuya, Sakai Yoshio, Harada Kenichi, Kawaguchi Kazunori, Takabatake Hisashi, Kitagawa Hirohisa, Wada Takashi, Honda Masao, Ohta Tetsuo, Nakanuma Yasuni, Kaneko Shuichi.
    Inflammatory features of pancreatic cancer highlighted by monocytes/macrophages and CD 4+ T cells with clinical impact. Cancer Science. 2015; 106(6): 672-686. doi:10.1111/cas.12663.
  • Inaba Yuka, Furutani Tomoko, Kimura Kumi, Watanabe Hitoshi, Haga Sanae, Kido Yoshiaki, Matsumoto Michihiro, Yamamoto Yasuhiko, Harada Kenichi, Kaneko Shuichi, Oyadomari Seiichi, Ozaki Michitaka, Kasuga Masato, Inoue Hiroshi.
    Growth arrest and DNA damage‐inducible 34 regulates liver regeneration in hepatic steatosis in mice. Hepatol.. 2015; 61(4): 1343-1356. doi:10.1002/hep.27619.
  • Sugimori Naomi, Espinoza J. Luis, Trung Ly Quoc, Takami Akiyoshi, Kondo Yukio, An Dao Thi, Sasaki Motoko, Wakayama Tomohiko, Nakao Shinji.
    Paraptosis Cell Death Induction by the Thiamine Analog Benfotiamine in Leukemia Cells. PLoS ONE. 2015; 10(4): e0120709. doi:10.1371/journal.pone.0120709.
  • Tominaga Tetsuro, Abo Takafumi, Kinoshita Naoe, Murakami Tomonori, Sato Yasunori, Nakanuma Yasuni, Harada Kenich, Masuda Junichi, Nagayasu Takeshi, Nanashima Atsushi.
    A variant of multicystic biliary hamartoma presenting as an intrahepatic cystic neoplasm. Clin J Gastroenterol. 2015; 8(3): 162-166. doi:10.1007/s12328-015-0574-y.
  • Nitta Takeo, Nakanuma Yasuni, Sato Yasunori, Hirano Satoshi, Pairojkul Chawalit.
    Pathological characteristics of intraductal polypoid neoplasms of bile ducts in Thailand. Int J Clin Exp Pathol. 2015; 8(7): 8284-8290. .
  • Sasaki Motoko, Hsu Maylee, Yeh Matthew M., Nakanuma Yasuni.
    In recurrent primary biliary cirrhosis after liver transplantation, biliary epithelial cells show increased expression of mitochondrial proteins. Virchows Arch. 2015; 467(4): 417-425. doi:10.1007/s00428-015-1819-3.
  • Sasaki Motoko, Nakanuma Yasuni.
    Serum Amyloid A-Positive Hepatocellular Neoplasm: A New Type of Tumor Arising in Patients with Advanced Alcoholic Disease. Dig Dis. 2015; 33(5): 648-654. doi:10.1159/000438474.
  • Shimoda Shinji, Hisamoto Satomi, Harada Kenichi, Iwasaka Sho, Chong Yong, Nakamura Minoru, Bekki Yuki, Yoshizumi Tomoharu, Shirabe Ken, Ikegami Toru, Maehara Yoshihiko, He Xiao‐Song, Gershwin M. Eric, Akashi Koichi.
    Natural killer cells regulate T cell immune responses in primary biliary cirrhosis. Hepatol.. 2015; 62(6): 1817-1827. doi:10.1002/hep.28122.

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2014

  1. Kakuda Y, Harada K, Nakanuma Y. Canals of Hering loss relates to the progression of the histological stages of primary biliary cirrhosis. J Clin Pathol. 2014, 68(2), 141-147. doi:10.1136/jclinpath-2014-202417.
  2. Nakanuma Y, Sasaki M, Harada K. Autophagy and senescence in fibrosing cholangiopathies. J Hepatol. 2014, 62(4), 934-945. doi:10.1016/j.jhep.2014.11.027.
  3. Nakamura M, Kondo H, Tanaka A, Komori A, Ito M, Yamamoto K, Ohira H, Zeniya M, Hashimoto E, Honda M, Kaneko S, Ueno Y, Kikuchi K, Shimoda S, Harada K, Arai K, Miyake Y, Abe M, Taniai M, Saibara T, Sakisaka S, Takikawa H, Onji M, Tsubouchi H, Nakanuma Y, Ishibashi H. Autoantibody status and histological variables influence biochemical response to treatment and long-term outcomes in Japanese patients with primary biliary cirrhosis: Biochemical response and outcome in PBC. Hepatol Res. 2014, 45(8), 846-855. doi:10.1111/hepr.12423.
  4. Floreani A, Spinazzè A, Caballeria L, Reig A, Cazzagon N, Franceschet I, Buja A, Furlan P, Harada K, Leung P, Gershwin M, Pares A. Extrahepatic Malignancies in Primary Biliary Cirrhosis: A Comparative Study at Two European Centers. Clinic Rev Allerg Immunol. 2014, 48(2-3), 254-262. doi:10.1007/s12016-014-8446-7.
  5. Tsutsui A, Bando Y, Sato Y, Miyake H, Sawada-Kitamura S, Shibata H, Kakuda Y, Harada K, Sasaki M, Nakanuma Y. Biliary adenofibroma with ominous features of imminent malignant changes. Clin J Gastroenterol. 2014, 7(5), 441-448. doi:10.1007/s12328-014-0523-1.
  6. Mizushima I, Inoue D, Yamamoto M, Yamada K, Saeki T, Ubara Y, Matsui S, Masaki Y, Wada T, Kasashima S, Harada K, Takahashi H, Notohara K, Nakanuma Y, Umehara H, Yamagishi M, Kawano M. Clinical course after corticosteroid therapy in IgG4-related aortitis/periaortitis and periarteritis: a retrospective multicenter study. Arthritis Res Ther. 2014, 16(4), R156. doi:10.1186/ar4671.
  7. Sato Y, Kubo S, Takemura S, Sugawara Y, Tanaka S, Fujikawa M, Arimoto A, Harada K, Sasaki M, Nakanuma Y. Different carcinogenic process in cholangiocarcinoma cases epidemically developing among workers of a printing company in Japan. Int J Clin Exp Pathol. 2014, 7(8), 4745-4754. .
  8. Nitta T, Sato Y, Ren X, Harada K, Sasaki M, Hirano S, Nakanuma Y. Autophagy may promote carcinoma cell invasion and correlate with poor prognosis in cholangiocarcinoma. Int J Clin Exp Pathol. 2014, 7(8), 4913-4921. .
  9. Harada K, Nakanuma Y. Cholangiocarcinoma with respect to IgG4 Reaction. Int J Hepatol. 2014, 2014NA, 1-8. doi:10.1155/2014/803876.
  10. Takemoto R, Miyake Y, Harada K, Nakanuma Y, Moriya A, Ando M, Hirohata M, Yamamoto K. Overlap of IgG4-related Sclerosing Cholangitis and Primary Biliary Cirrhosis. Intern Med. 2014, 53(13), 1429-1433. doi:10.2169/internalmedicine.53.2250.
  11. Nakanuma Y, Tsutsui A, Ren X, Harada K, Sato Y, Sasaki M. What Are the Precursor and Early Lesions of Peripheral Intrahepatic Cholangiocarcinoma?. Int J Hepatol. 2014, 2014NA, e805973. doi:10.1155/2014/805973.
  12. Sato Y, Harada K, Sasaki M, Nakanuma Y. Histological Characterization of Biliary Intraepithelial Neoplasia with respect to Pancreatic Intraepithelial Neoplasia. Int J Hepatol. 2014, 2014NA, 1-7. doi:10.1155/2014/678260.
  13. Harada K, Yuko K, Sato Y, Ikeda H, Nakanuma Y. Significance of oestrogen-related receptor γ on biliary epithelial cells in the pathogenesis of primary biliary cirrhosis. J Clin Pathol. 2014, 67(7), 566-572. doi:10.1136/jclinpath-2013-201735.
  14. Tajima H, Kitagawa H, Shoji M, Watanabe T, Nakanuma S, Okamoto K, Sakai S, Kinoshita J, Makino I, Furukawa H, Nakamura K, Hayashi H, Oyama K, Inokuchi M, Nakagawara H, Miyashita T, Itoh H, Takamura H, Ninomiya I, Fushida S, Fujimura T, Ohta T, Satoh H, Ikeda H, Harada K, Nakanuma Y. Pancreatic body adenocarcinoma with neuroendocrine tumor characteristics: A case report. Oncol Lett. 2014, 7(4), 1049-1052. doi:10.3892/ol.2014.1873.
  15. Ren X, Sato Y, Harada K, Sasaki M, Furubo S, Song J, Nakanuma Y. Activation of the PI3K/mTOR Pathway Is Involved in Cystic Proliferation of Cholangiocytes of the PCK Rat. PLoS ONE. 2014, 9(1), e87660. doi:10.1371/journal.pone.0087660.
  16. Sato Y, Harada K, Sasaki M, Nakanuma Y. Cystic and micropapillary epithelial changes of peribiliary glands might represent a precursor lesion of biliary epithelial neoplasms. Virchows Arch. 2014, 464(2), 157-163. doi:10.1007/s00428-014-1537-2.

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